A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response

The Replication Stress Response (RSR) is a signaling network that recognizes challenges to DNA replication and coordinates diverse DNA repair and cell-cycle checkpoint pathways. Gemcitabine is a nucleoside analogue that causes cytotoxicity by inducing DNA replication blocks. Using a synthetic lethal...

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Detalles Bibliográficos
Autores principales: Smith, Scott C., Petrova, Aleksandra V., Madden, Matthew Z., Wang, Hongyan, Pan, Yunfeng, Warren, Matthew D., Hardy, Claire W., Liang, Dong, Liu, Elaine A., Robinson, M. Hope, Rudra, Soumon, Wang, Jie, Ehdaivand, Shahrzad, Torres, Mylin A., Wang, Ya, Yu, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191414/
https://www.ncbi.nlm.nih.gov/pubmed/25217585
http://dx.doi.org/10.1093/nar/gku840

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