SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression

Polycomb group (PcG) complexes regulate cellular identity through epigenetic programming of chromatin. Here, we show that SSX2, a germline-specific protein ectopically expressed in melanoma and other types of human cancers, is a chromatin-associated protein that antagonizes BMI1 and EZH2 PcG body fo...

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Detalles Bibliográficos
Autores principales: Gjerstorff, Morten Frier, Relster, Mette Marie, Greve, Katrine Buch Viden, Moeller, Jesper Bonnet, Elias, Daniel, Lindgreen, Jonas Nørrelund, Schmidt, Steffen, Mollenhauer, Jan, Voldborg, Bjørn, Pedersen, Christina Bøg, Brückmann, Nadine Heidi, Møllegaard, Niels Erik, Ditzel, Henrik Jørn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191419/
https://www.ncbi.nlm.nih.gov/pubmed/25249625
http://dx.doi.org/10.1093/nar/gku852

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