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Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress

ZNF509 is unique among POK family proteins in that four isoforms are generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). Here, we investigated the functions of ZNF509 isoforms in respons...

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Detalles Bibliográficos
Autores principales:	Jeon, Bu-Nam, Kim, Min-Kyeong, Yoon, Jae-Hyeon, Kim, Min-Young, An, Haemin, Noh, Hee-Jin, Choi, Won-Il, Koh, Dong-In, Hur, Man-Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191422/ https://www.ncbi.nlm.nih.gov/pubmed/25245946 http://dx.doi.org/10.1093/nar/gku857

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