Cargando…

Replication stress by Py–Im polyamides induces a non-canonical ATR-dependent checkpoint response

Pyrrole–imidazole polyamides targeted to the androgen response element were cytotoxic in multiple cell lines, independent of intact androgen receptor signaling. Polyamide treatment induced accumulation of S-phase cells and of PCNA replication/repair foci. Activation of a cell cycle checkpoint respon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martínez, Thomas F., Phillips, John W., Karanja, Kenneth K., Polaczek, Piotr, Wang, Chieh-Mei, Li, Benjamin C., Campbell, Judith L., Dervan, Peter B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191428/ https://www.ncbi.nlm.nih.gov/pubmed/25249630 http://dx.doi.org/10.1093/nar/gku866

Ejemplares similares

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
por: Liu, Shengqin, et al.
Publicado: (2012)

PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway
por: Lin, Yu-Fen, et al.
Publicado: (2018)

Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1
por: Kang, Tae-Hong, et al.
Publicado: (2014)

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
por: Choi, Jun-Hyuk, et al.
Publicado: (2009)

ADAR1 links R-loop homeostasis to ATR activation in replication stress response
por: Zhang, Biao, et al.
Publicado: (2023)

A kinetochore-based ATM/ATR-independent DNA damage checkpoint maintains genomic integrity in trypanosomes
por: Zhou, Qing, et al.
Publicado: (2019)

The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response
por: Wang, Lili, et al.
Publicado: (2021)

Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe
por: Patel, Jinal A, et al.
Publicado: (2023)

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
por: Rizzo, Angela, et al.
Publicado: (2009)

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress
por: Lloyd, Rebecca L, et al.
Publicado: (2021)

Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase
por: Kang, Yujin, et al.
Publicado: (2023)

RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling
por: Deshar, Rakesh, et al.
Publicado: (2019)

ATR contributes to telomere maintenance in human cells
por: Pennarun, Gaëlle, et al.
Publicado: (2010)

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR
por: Dhoonmoon, Ashna, et al.
Publicado: (2020)

Replication fork integrity and intra-S phase checkpoint suppress gene amplification
por: Kondratova, Anna, et al.
Publicado: (2015)

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
por: Liu, Wenpeng, et al.
Publicado: (2023)

A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination
por: Dubois, Jean-Christophe, et al.
Publicado: (2017)

Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts
por: Recolin, Bénédicte, et al.
Publicado: (2012)

Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation
por: Minca, Eugen C., et al.
Publicado: (2011)

Monitoring Replication Protein A (RPA) dynamics in homologous recombination through site-specific incorporation of non-canonical amino acids
por: Pokhrel, Nilisha, et al.
Publicado: (2017)

Canonical and novel non-canonical activities of the Holliday junction resolvase Yen1
por: Carreira, Raquel, et al.
Publicado: (2021)

Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response
por: Nishida, Hiroshi, et al.
Publicado: (2009)

The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing
por: Frum, Rebecca A., et al.
Publicado: (2014)

AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair
por: Jarrett, Stuart G., et al.
Publicado: (2016)

Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint
por: Zucca, Elisa, et al.
Publicado: (2013)

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage
por: Vadnais, Charles, et al.
Publicado: (2012)

ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells
por: Kim, Dongsung, et al.
Publicado: (2018)

Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress
por: Basile, Giorgia, et al.
Publicado: (2014)

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage
por: Gamper, Armin M., et al.
Publicado: (2013)

Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription
por: Velichko, Artem K, et al.
Publicado: (2019)

NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest
por: Sun, Xiaohui, et al.
Publicado: (2020)

APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus
por: Li, Jia, et al.
Publicado: (2022)

RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling
por: Kar, Ananya, et al.
Publicado: (2015)

Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
por: Landsverk, Helga B, et al.
Publicado: (2019)

The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction
por: Katsura, Mari, et al.
Publicado: (2009)

ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice
por: Entezam, Ali, et al.
Publicado: (2009)

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation
por: Sokka, Miiko, et al.
Publicado: (2015)

A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair
por: Tomida, Junya, et al.
Publicado: (2013)

Non-canonical LexA proteins regulate the SOS response in the Bacteroidetes
por: Sánchez-Osuna, Miquel, et al.
Publicado: (2021)

A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine–DNA glycosylase
por: Li, Haoquan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vr2ojmrjf18g1gakct2phl60nb