TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas

CONTEXT: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. OBJECTIVES: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognos...

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Detalles Bibliográficos
Autores principales: Melo, Miguel, da Rocha, Adriana Gaspar, Vinagre, João, Batista, Rui, Peixoto, Joana, Tavares, Catarina, Celestino, Ricardo, Almeida, Ana, Salgado, Catarina, Eloy, Catarina, Castro, Patrícia, Prazeres, Hugo, Lima, Jorge, Amaro, Teresina, Lobo, Cláudia, Martins, Maria João, Moura, Margarida, Cavaco, Branca, Leite, Valeriano, Cameselle-Teijeiro, José Manuel, Carrilho, Francisco, Carvalheiro, Manuela, Máximo, Valdemar, Sobrinho-Simões, Manuel, Soares, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2014
Materias:
Hot Topics in Translational Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191548/
https://www.ncbi.nlm.nih.gov/pubmed/24476079
http://dx.doi.org/10.1210/jc.2013-3734

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