Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

[Image: see text] Toll-like receptor (TLR) 7 and 8 agonists are potential vaccine adjuvants, since they directly activate APCs and enhance Th1-driven immune responses. Previous SAR investigations in several scaffolds of small molecule TLR7/8 activators pointed to the strict dependence of the selecti...

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Detalles Bibliográficos
Autores principales: Yoo, Euna, Salunke, Deepak B., Sil, Diptesh, Guo, Xiaoqiang, Salyer, Alex C. D., Hermanson, Alec R., Kumar, Manoj, Malladi, Subbalakshmi S., Balakrishna, Rajalakshmi, Thompson, Ward H., Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191598/
https://www.ncbi.nlm.nih.gov/pubmed/25192394
http://dx.doi.org/10.1021/jm500744f

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