Identification of the First Inhibitor of the GBP1:PIM1 Interaction. Implications for the Development of a New Class of Anticancer Agents against Paclitaxel Resistant Cancer Cells

[Image: see text] Class III β-tubulin plays a prominent role in the development of drug resistance to paclitaxel by allowing the incorporation of the GBP1 GTPase into microtubules. Once in the cytoskeleton, GBP1 binds to prosurvival kinases such as PIM1 and initiates a signaling pathway that induces...

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Detalles Bibliográficos
Autores principales: Andreoli, Mirko, Persico, Marco, Kumar, Ajay, Orteca, Nausicaa, Kumar, Vineet, Pepe, Antonella, Mahalingam, Sakkarapalayam, Alegria, Antonio E., Petrella, Lella, Sevciunaite, Laima, Camperchioli, Alessia, Mariani, Marisa, Di Dato, Antonio, Novellino, Ettore, Scambia, Giovanni, Malhotra, Sanjay V., Ferlini, Cristiano, Fattorusso, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191604/
https://www.ncbi.nlm.nih.gov/pubmed/25211704
http://dx.doi.org/10.1021/jm5009902

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