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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT; per-allele odds ratio [OR] = 0.79; 95% confidence interval [CI] =...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191666/ https://www.ncbi.nlm.nih.gov/pubmed/25086665 http://dx.doi.org/10.1038/ng.3052 |
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| author | Wolpin, Brian M. Rizzato, Cosmeri Kraft, Peter Kooperberg, Charles Petersen, Gloria M. Wang, Zhaoming Arslan, Alan A. Beane-Freeman, Laura Bracci, Paige M. Buring, Julie Canzian, Federico Duell, Eric J. Gallinger, Steven Giles, Graham G. Goodman, Gary E. Goodman, Phyllis J. Jacobs, Eric J. Kamineni, Aruna Klein, Alison P. Kolonel, Laurence N. Kulke, Matthew H. Li, Donghui Malats, Núria Olson, Sara H. Risch, Harvey A. Sesso, Howard D. Visvanathan, Kala White, Emily Zheng, Wei Abnet, Christian C. Albanes, Demetrius Andreotti, Gabriella Austin, Melissa A. Barfield, Richard Basso, Daniela Berndt, Sonja I. Boutron-Ruault, Marie-Christine Brotzman, Michelle Büchler, Markus W. Bueno-de-Mesquita, H. Bas Bugert, Peter Burdette, Laurie Campa, Daniele Caporaso, Neil E. Capurso, Gabriele Chung, Charles Cotterchio, Michelle Costello, Eithne Elena, Joanne Funel, Niccola Gaziano, J. Michael Giese, Nathalia A. Giovannucci, Edward L. Goggins, Michael Gorman, Megan J. Gross, Myron Haiman, Christopher A. Hassan, Manal Helzlsouer, Kathy J. Henderson, Brian E. Holly, Elizabeth A. Hu, Nan Hunter, David J. Innocenti, Federico Jenab, Mazda Kaaks, Rudolf Key, Timothy J. Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis Krogh, Vittorio Kupcinskas, Juozas Kurtz, Robert C. LaCroix, Andrea Landi, Maria T. Landi, Stefano Le Marchand, Loic Mambrini, Andrea Mannisto, Satu Milne, Roger L. Nakamura, Yusuke Oberg, Ann L. Owzar, Kouros Patel, Alpa V. Peeters, Petra H. M. Peters, Ulrike Pezzilli, Raffaele Piepoli, Ada Porta, Miquel Real, Francisco X. Riboli, Elio Rothman, Nathaniel Scarpa, Aldo Shu, Xiao-Ou Silverman, Debra T. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata Taylor, Philip R. Theodoropoulos, George E. Thornquist, Mark Tjønneland, Anne Tobias, Geoffrey S. Trichopoulos, Dimitrios Vodicka, Pavel Wactawski-Wende, Jean Wentzensen, Nicolas Wu, Chen Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne Hoover, Robert Hartge, Patricia Fuchs, Charles Chanock, Stephen J. Stolzenberg-Solomon, Rachael S. Amundadottir, Laufey T. |
| author_facet | Wolpin, Brian M. Rizzato, Cosmeri Kraft, Peter Kooperberg, Charles Petersen, Gloria M. Wang, Zhaoming Arslan, Alan A. Beane-Freeman, Laura Bracci, Paige M. Buring, Julie Canzian, Federico Duell, Eric J. Gallinger, Steven Giles, Graham G. Goodman, Gary E. Goodman, Phyllis J. Jacobs, Eric J. Kamineni, Aruna Klein, Alison P. Kolonel, Laurence N. Kulke, Matthew H. Li, Donghui Malats, Núria Olson, Sara H. Risch, Harvey A. Sesso, Howard D. Visvanathan, Kala White, Emily Zheng, Wei Abnet, Christian C. Albanes, Demetrius Andreotti, Gabriella Austin, Melissa A. Barfield, Richard Basso, Daniela Berndt, Sonja I. Boutron-Ruault, Marie-Christine Brotzman, Michelle Büchler, Markus W. Bueno-de-Mesquita, H. Bas Bugert, Peter Burdette, Laurie Campa, Daniele Caporaso, Neil E. Capurso, Gabriele Chung, Charles Cotterchio, Michelle Costello, Eithne Elena, Joanne Funel, Niccola Gaziano, J. Michael Giese, Nathalia A. Giovannucci, Edward L. Goggins, Michael Gorman, Megan J. Gross, Myron Haiman, Christopher A. Hassan, Manal Helzlsouer, Kathy J. Henderson, Brian E. Holly, Elizabeth A. Hu, Nan Hunter, David J. Innocenti, Federico Jenab, Mazda Kaaks, Rudolf Key, Timothy J. Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis Krogh, Vittorio Kupcinskas, Juozas Kurtz, Robert C. LaCroix, Andrea Landi, Maria T. Landi, Stefano Le Marchand, Loic Mambrini, Andrea Mannisto, Satu Milne, Roger L. Nakamura, Yusuke Oberg, Ann L. Owzar, Kouros Patel, Alpa V. Peeters, Petra H. M. Peters, Ulrike Pezzilli, Raffaele Piepoli, Ada Porta, Miquel Real, Francisco X. Riboli, Elio Rothman, Nathaniel Scarpa, Aldo Shu, Xiao-Ou Silverman, Debra T. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata Taylor, Philip R. Theodoropoulos, George E. Thornquist, Mark Tjønneland, Anne Tobias, Geoffrey S. Trichopoulos, Dimitrios Vodicka, Pavel Wactawski-Wende, Jean Wentzensen, Nicolas Wu, Chen Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne Hoover, Robert Hartge, Patricia Fuchs, Charles Chanock, Stephen J. Stolzenberg-Solomon, Rachael S. Amundadottir, Laufey T. |
| author_sort | Wolpin, Brian M. |
| collection | PubMed |
| description | We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT; per-allele odds ratio [OR] = 0.79; 95% confidence interval [CI] = 0.74–0.84; P = 3.0×10(−12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2; OR = 1.46; 95% CI = 1.30–1.65; P = 1.1×10(−10)), rs9581943 at 13q12.2 (PDX1; OR = 1.15; 95% CI = 1.10–1.20; P = 2.4×10(−9)), and rs16986825 at 22q12.1 (ZNRF3; OR = 1.18; 95% CI = 1.12–1.25; P = 1.2×10(−8)). An independent signal was identified in exon 2 of TERT at the established region 5p15.33 (rs2736098; OR = 0.80; 95% CI = 0.76–0.85; P = 9.8×10(−14)). We also identified a locus at 8q24.21 (rs1561927; P = 1.3×10(−7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study has identified multiple new susceptibility alleles for pancreatic cancer worthy of follow-up studies. |
| format | Online Article Text |
| id | pubmed-4191666 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41916662015-03-01 Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer Wolpin, Brian M. Rizzato, Cosmeri Kraft, Peter Kooperberg, Charles Petersen, Gloria M. Wang, Zhaoming Arslan, Alan A. Beane-Freeman, Laura Bracci, Paige M. Buring, Julie Canzian, Federico Duell, Eric J. Gallinger, Steven Giles, Graham G. Goodman, Gary E. Goodman, Phyllis J. Jacobs, Eric J. Kamineni, Aruna Klein, Alison P. Kolonel, Laurence N. Kulke, Matthew H. Li, Donghui Malats, Núria Olson, Sara H. Risch, Harvey A. Sesso, Howard D. Visvanathan, Kala White, Emily Zheng, Wei Abnet, Christian C. Albanes, Demetrius Andreotti, Gabriella Austin, Melissa A. Barfield, Richard Basso, Daniela Berndt, Sonja I. Boutron-Ruault, Marie-Christine Brotzman, Michelle Büchler, Markus W. Bueno-de-Mesquita, H. Bas Bugert, Peter Burdette, Laurie Campa, Daniele Caporaso, Neil E. Capurso, Gabriele Chung, Charles Cotterchio, Michelle Costello, Eithne Elena, Joanne Funel, Niccola Gaziano, J. Michael Giese, Nathalia A. Giovannucci, Edward L. Goggins, Michael Gorman, Megan J. Gross, Myron Haiman, Christopher A. Hassan, Manal Helzlsouer, Kathy J. Henderson, Brian E. Holly, Elizabeth A. Hu, Nan Hunter, David J. Innocenti, Federico Jenab, Mazda Kaaks, Rudolf Key, Timothy J. Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis Krogh, Vittorio Kupcinskas, Juozas Kurtz, Robert C. LaCroix, Andrea Landi, Maria T. Landi, Stefano Le Marchand, Loic Mambrini, Andrea Mannisto, Satu Milne, Roger L. Nakamura, Yusuke Oberg, Ann L. Owzar, Kouros Patel, Alpa V. Peeters, Petra H. M. Peters, Ulrike Pezzilli, Raffaele Piepoli, Ada Porta, Miquel Real, Francisco X. Riboli, Elio Rothman, Nathaniel Scarpa, Aldo Shu, Xiao-Ou Silverman, Debra T. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata Taylor, Philip R. Theodoropoulos, George E. Thornquist, Mark Tjønneland, Anne Tobias, Geoffrey S. Trichopoulos, Dimitrios Vodicka, Pavel Wactawski-Wende, Jean Wentzensen, Nicolas Wu, Chen Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne Hoover, Robert Hartge, Patricia Fuchs, Charles Chanock, Stephen J. Stolzenberg-Solomon, Rachael S. Amundadottir, Laufey T. Nat Genet Article We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT; per-allele odds ratio [OR] = 0.79; 95% confidence interval [CI] = 0.74–0.84; P = 3.0×10(−12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2; OR = 1.46; 95% CI = 1.30–1.65; P = 1.1×10(−10)), rs9581943 at 13q12.2 (PDX1; OR = 1.15; 95% CI = 1.10–1.20; P = 2.4×10(−9)), and rs16986825 at 22q12.1 (ZNRF3; OR = 1.18; 95% CI = 1.12–1.25; P = 1.2×10(−8)). An independent signal was identified in exon 2 of TERT at the established region 5p15.33 (rs2736098; OR = 0.80; 95% CI = 0.76–0.85; P = 9.8×10(−14)). We also identified a locus at 8q24.21 (rs1561927; P = 1.3×10(−7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study has identified multiple new susceptibility alleles for pancreatic cancer worthy of follow-up studies. 2014-08-03 2014-09 /pmc/articles/PMC4191666/ /pubmed/25086665 http://dx.doi.org/10.1038/ng.3052 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Wolpin, Brian M. Rizzato, Cosmeri Kraft, Peter Kooperberg, Charles Petersen, Gloria M. Wang, Zhaoming Arslan, Alan A. Beane-Freeman, Laura Bracci, Paige M. Buring, Julie Canzian, Federico Duell, Eric J. Gallinger, Steven Giles, Graham G. Goodman, Gary E. Goodman, Phyllis J. Jacobs, Eric J. Kamineni, Aruna Klein, Alison P. Kolonel, Laurence N. Kulke, Matthew H. Li, Donghui Malats, Núria Olson, Sara H. Risch, Harvey A. Sesso, Howard D. Visvanathan, Kala White, Emily Zheng, Wei Abnet, Christian C. Albanes, Demetrius Andreotti, Gabriella Austin, Melissa A. Barfield, Richard Basso, Daniela Berndt, Sonja I. Boutron-Ruault, Marie-Christine Brotzman, Michelle Büchler, Markus W. Bueno-de-Mesquita, H. Bas Bugert, Peter Burdette, Laurie Campa, Daniele Caporaso, Neil E. Capurso, Gabriele Chung, Charles Cotterchio, Michelle Costello, Eithne Elena, Joanne Funel, Niccola Gaziano, J. Michael Giese, Nathalia A. Giovannucci, Edward L. Goggins, Michael Gorman, Megan J. Gross, Myron Haiman, Christopher A. Hassan, Manal Helzlsouer, Kathy J. Henderson, Brian E. Holly, Elizabeth A. Hu, Nan Hunter, David J. Innocenti, Federico Jenab, Mazda Kaaks, Rudolf Key, Timothy J. Khaw, Kay-Tee Klein, Eric A. Kogevinas, Manolis Krogh, Vittorio Kupcinskas, Juozas Kurtz, Robert C. LaCroix, Andrea Landi, Maria T. Landi, Stefano Le Marchand, Loic Mambrini, Andrea Mannisto, Satu Milne, Roger L. Nakamura, Yusuke Oberg, Ann L. Owzar, Kouros Patel, Alpa V. Peeters, Petra H. M. Peters, Ulrike Pezzilli, Raffaele Piepoli, Ada Porta, Miquel Real, Francisco X. Riboli, Elio Rothman, Nathaniel Scarpa, Aldo Shu, Xiao-Ou Silverman, Debra T. Soucek, Pavel Sund, Malin Talar-Wojnarowska, Renata Taylor, Philip R. Theodoropoulos, George E. Thornquist, Mark Tjønneland, Anne Tobias, Geoffrey S. Trichopoulos, Dimitrios Vodicka, Pavel Wactawski-Wende, Jean Wentzensen, Nicolas Wu, Chen Yu, Herbert Yu, Kai Zeleniuch-Jacquotte, Anne Hoover, Robert Hartge, Patricia Fuchs, Charles Chanock, Stephen J. Stolzenberg-Solomon, Rachael S. Amundadottir, Laufey T. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| title | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| title_full | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| title_fullStr | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| title_full_unstemmed | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| title_short | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| title_sort | genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191666/ https://www.ncbi.nlm.nih.gov/pubmed/25086665 http://dx.doi.org/10.1038/ng.3052 |
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