Predicting the Functions and Specificity of Triterpenoid Synthases: A Mechanism-Based Multi-intermediate Docking Approach

Terpenoid synthases construct the carbon skeletons of tens of thousands of natural products. To predict functions and specificity of triterpenoid synthases, a mechanism-based, multi-intermediate docking approach is proposed. In addition to enzyme function prediction, other potential applications of...

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Detalles Bibliográficos
Autores principales: Tian, Bo-Xue, Wallrapp, Frank H., Holiday, Gemma L., Chow, Jeng-Yeong, Babbitt, Patricia C., Poulter, C. Dale, Jacobson, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191879/
https://www.ncbi.nlm.nih.gov/pubmed/25299649
http://dx.doi.org/10.1371/journal.pcbi.1003874

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