The SH2 Domain Regulates c-Abl Kinase Activation by a Cyclin-Like Mechanism and Remodulation of the Hinge Motion

Regulation of the c-Abl (ABL1) tyrosine kinase is important because of its role in cellular signaling, and its relevance in the leukemiogenic counterpart (BCR-ABL). Both auto-inhibition and full activation of c-Abl are regulated by the interaction of the catalytic domain with the Src Homology 2 (SH2...

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Detalles Bibliográficos
Autores principales: Dölker, Nicole, Górna, Maria W., Sutto, Ludovico, Torralba, Antonio S., Superti-Furga, Giulio, Gervasio, Francesco L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191882/
https://www.ncbi.nlm.nih.gov/pubmed/25299346
http://dx.doi.org/10.1371/journal.pcbi.1003863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191882/
https://www.ncbi.nlm.nih.gov/pubmed/25299346
http://dx.doi.org/10.1371/journal.pcbi.1003863

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