Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency

As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relationship in XPG patients. Defects in XPG can cause ei...

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Detalles Bibliográficos
Autores principales: Barnhoorn, Sander, Uittenboogaard, Lieneke M., Jaarsma, Dick, Vermeij, Wilbert P., Tresini, Maria, Weymaere, Michael, Menoni, Hervé, Brandt, Renata M. C., de Waard, Monique C., Botter, Sander M., Sarker, Altaf H., Jaspers, Nicolaas G. J., van der Horst, Gijsbertus T. J., Cooper, Priscilla K., Hoeijmakers, Jan H. J., van der Pluijm, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191938/
https://www.ncbi.nlm.nih.gov/pubmed/25299392
http://dx.doi.org/10.1371/journal.pgen.1004686

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