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The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML
NPM1 mutations represent frequent genetic alterations in patients with acute myeloid leukemia (AML) associated with a favorable prognosis. Different types of NPM1 mutations have been described. The purpose of our study was to evaluate the relevance of different NPM1 mutation types with regard to cli...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192029/ https://www.ncbi.nlm.nih.gov/pubmed/25299584 http://dx.doi.org/10.1371/journal.pone.0109759 |
| _version_ | 1782338738099060736 |
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| author | Pastore, Friederike Greif, Philipp A. Schneider, Stephanie Ksienzyk, Bianka Mellert, Gudrun Zellmeier, Evelyn Braess, Jan Sauerland, Cristina M. Heinecke, Achim Krug, Utz Berdel, Wolfgang E. Buechner, Thomas Woermann, Bernhard Hiddemann, Wolfgang Spiekermann, Karsten |
| author_facet | Pastore, Friederike Greif, Philipp A. Schneider, Stephanie Ksienzyk, Bianka Mellert, Gudrun Zellmeier, Evelyn Braess, Jan Sauerland, Cristina M. Heinecke, Achim Krug, Utz Berdel, Wolfgang E. Buechner, Thomas Woermann, Bernhard Hiddemann, Wolfgang Spiekermann, Karsten |
| author_sort | Pastore, Friederike |
| collection | PubMed |
| description | NPM1 mutations represent frequent genetic alterations in patients with acute myeloid leukemia (AML) associated with a favorable prognosis. Different types of NPM1 mutations have been described. The purpose of our study was to evaluate the relevance of different NPM1 mutation types with regard to clinical outcome. Our analyses were based on 349 NPM1-mutated AML patients treated in the AMLCG99 trial. Complete remission rates, overall survival and relapse-free survival were not significantly different between patients with NPM1 type A or rare type mutations. The NPM1 mutation type does not seem to play a role in risk stratification of cytogenetically normal AML. |
| format | Online Article Text |
| id | pubmed-4192029 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41920292014-10-14 The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML Pastore, Friederike Greif, Philipp A. Schneider, Stephanie Ksienzyk, Bianka Mellert, Gudrun Zellmeier, Evelyn Braess, Jan Sauerland, Cristina M. Heinecke, Achim Krug, Utz Berdel, Wolfgang E. Buechner, Thomas Woermann, Bernhard Hiddemann, Wolfgang Spiekermann, Karsten PLoS One Research Article NPM1 mutations represent frequent genetic alterations in patients with acute myeloid leukemia (AML) associated with a favorable prognosis. Different types of NPM1 mutations have been described. The purpose of our study was to evaluate the relevance of different NPM1 mutation types with regard to clinical outcome. Our analyses were based on 349 NPM1-mutated AML patients treated in the AMLCG99 trial. Complete remission rates, overall survival and relapse-free survival were not significantly different between patients with NPM1 type A or rare type mutations. The NPM1 mutation type does not seem to play a role in risk stratification of cytogenetically normal AML. Public Library of Science 2014-10-09 /pmc/articles/PMC4192029/ /pubmed/25299584 http://dx.doi.org/10.1371/journal.pone.0109759 Text en © 2014 Pastore et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Pastore, Friederike Greif, Philipp A. Schneider, Stephanie Ksienzyk, Bianka Mellert, Gudrun Zellmeier, Evelyn Braess, Jan Sauerland, Cristina M. Heinecke, Achim Krug, Utz Berdel, Wolfgang E. Buechner, Thomas Woermann, Bernhard Hiddemann, Wolfgang Spiekermann, Karsten The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML |
| title | The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML |
| title_full | The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML |
| title_fullStr | The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML |
| title_full_unstemmed | The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML |
| title_short | The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML |
| title_sort | npm1 mutation type has no impact on survival in cytogenetically normal aml |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192029/ https://www.ncbi.nlm.nih.gov/pubmed/25299584 http://dx.doi.org/10.1371/journal.pone.0109759 |
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