Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia

INTRODUCTION: Mild therapeutic hypothermia is an increasingly recognised treatment option to reduce perihemorrhagic edema in severe intracerebral hemorrhage. CASE DESCRIPTION: We report the case of a 77-year old woman with atypical intracerebral hemorrhage that was treated with mild hypothermia in a...

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Detalles Bibliográficos
Autores principales: Regensburger, Martin, Huttner, Hagen B, Doerfler, Arnd, Schwab, Stefan, Staykov, Dimitre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192142/
https://www.ncbi.nlm.nih.gov/pubmed/25332856
http://dx.doi.org/10.1186/2193-1801-3-551
Descripción
Sumario:INTRODUCTION: Mild therapeutic hypothermia is an increasingly recognised treatment option to reduce perihemorrhagic edema in severe intracerebral hemorrhage. CASE DESCRIPTION: We report the case of a 77-year old woman with atypical intracerebral hemorrhage that was treated with mild hypothermia in addition to osmotic therapy. The patient’s urine subsequently showed a green discoloration. Urine discoloration was completely reversible upon discontinuation of propofol. DISCUSSION AND EVALUATION: Propofol-related urine discoloration may have been provoked by hypothermia. Due to the benign nature of this side effect, propofol should be stopped and gastrointestinal function should be supported. CONCLUSION: More studies are needed to show a causal role of hypothermia and related decreased enzymatic function.

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