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An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess

Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, may be due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion is stimulated by CRH, and we report a mouse model for...

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Detalles Bibliográficos
Autores principales:	Bentley, Liz, Esapa, Christopher T., Nesbit, M. Andrew, Head, Rosie A., Evans, Holly, Lath, Darren, Scudamore, Cheryl L., Hough, Tertius A., Podrini, Christine, Hannan, Fadil M., Fraser, William D., Croucher, Peter I., Brown, Matthew A., Brown, Steve D. M., Cox, Roger D., Thakker, Rajesh V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2014
Materias:	Glucocorticoids-CRH-ACTH-Adrenal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192286/ https://www.ncbi.nlm.nih.gov/pubmed/24302625 http://dx.doi.org/10.1210/en.2013-1247

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