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Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis

TOPIC: A meta-analysis of TCF4 and PTPRG gene variants in Fuchs' corneal dystrophy (FCD). CLINICAL RELEVANCE: To identify novel genetic markers in patients with FCD in different ethnic populations. METHODS: MEDLINE and EMBASE were searched for eligible genetic studies on TCF4 and PTPRG in FCD....

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Autores principales: Lau, Lawrence C. M., Ma, Li, Young, Alvin L., Rong, Shi Song, Jhanji, Vishal, Brelen, Marten E., Pang, Chi Pui, Chen, Li Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192317/
https://www.ncbi.nlm.nih.gov/pubmed/25299301
http://dx.doi.org/10.1371/journal.pone.0109142
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author Lau, Lawrence C. M.
Ma, Li
Young, Alvin L.
Rong, Shi Song
Jhanji, Vishal
Brelen, Marten E.
Pang, Chi Pui
Chen, Li Jia
author_facet Lau, Lawrence C. M.
Ma, Li
Young, Alvin L.
Rong, Shi Song
Jhanji, Vishal
Brelen, Marten E.
Pang, Chi Pui
Chen, Li Jia
author_sort Lau, Lawrence C. M.
collection PubMed
description TOPIC: A meta-analysis of TCF4 and PTPRG gene variants in Fuchs' corneal dystrophy (FCD). CLINICAL RELEVANCE: To identify novel genetic markers in patients with FCD in different ethnic populations. METHODS: MEDLINE and EMBASE were searched for eligible genetic studies on TCF4 and PTPRG in FCD. Odds ratios (OR) and 95% confidence intervals (CI) of each single-nucleotide polymorphism (SNP) in allelic, dominant and recessive models were estimated using fixed-effect model if I(2)<50% in the test for heterogeneity, otherwise the random effects model was used. RESULTS: Thirty-three records were obtained, with 8 being suitable for meta-analysis, which included five SNPs in TCF4 and two in PTPRG. There were 1610 FCD patients and 1565 controls tested for TCF4 rs613872. This SNP was strongly associated with FCD in Caucasians (P = 5.0×10(−106)), with the risk allele G conferring an OR of 3.95 (95% CI: 3.49–4.46). A further 4 TCF4 SNPs (rs17595731, rs2286812, rs618869 and rs9954153) were also significantly associated with FCD in Caucasians (P<10(−8)). However, we found no SNP associated with FCD in Chinese. In addition, there was no significant association between FCD and PTPRG. CONCLUSION: TCF4 rs613872 is strongly associated with FCD in Caucasians but not in Chinese, which may suggest ethnic diversity in FCD SNP associations. SNPs in PTPRG were not associated with FCD in Caucasians or Chinese populations. Results of this meta-analysis indicate the need for larger-scale and multi-ethnic genetic studies on FCD to further explore the associated gene variants and their roles on the mechanism and genetic basis of FCD.
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spelling pubmed-41923172014-10-14 Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis Lau, Lawrence C. M. Ma, Li Young, Alvin L. Rong, Shi Song Jhanji, Vishal Brelen, Marten E. Pang, Chi Pui Chen, Li Jia PLoS One Research Article TOPIC: A meta-analysis of TCF4 and PTPRG gene variants in Fuchs' corneal dystrophy (FCD). CLINICAL RELEVANCE: To identify novel genetic markers in patients with FCD in different ethnic populations. METHODS: MEDLINE and EMBASE were searched for eligible genetic studies on TCF4 and PTPRG in FCD. Odds ratios (OR) and 95% confidence intervals (CI) of each single-nucleotide polymorphism (SNP) in allelic, dominant and recessive models were estimated using fixed-effect model if I(2)<50% in the test for heterogeneity, otherwise the random effects model was used. RESULTS: Thirty-three records were obtained, with 8 being suitable for meta-analysis, which included five SNPs in TCF4 and two in PTPRG. There were 1610 FCD patients and 1565 controls tested for TCF4 rs613872. This SNP was strongly associated with FCD in Caucasians (P = 5.0×10(−106)), with the risk allele G conferring an OR of 3.95 (95% CI: 3.49–4.46). A further 4 TCF4 SNPs (rs17595731, rs2286812, rs618869 and rs9954153) were also significantly associated with FCD in Caucasians (P<10(−8)). However, we found no SNP associated with FCD in Chinese. In addition, there was no significant association between FCD and PTPRG. CONCLUSION: TCF4 rs613872 is strongly associated with FCD in Caucasians but not in Chinese, which may suggest ethnic diversity in FCD SNP associations. SNPs in PTPRG were not associated with FCD in Caucasians or Chinese populations. Results of this meta-analysis indicate the need for larger-scale and multi-ethnic genetic studies on FCD to further explore the associated gene variants and their roles on the mechanism and genetic basis of FCD. Public Library of Science 2014-10-09 /pmc/articles/PMC4192317/ /pubmed/25299301 http://dx.doi.org/10.1371/journal.pone.0109142 Text en © 2014 Lau et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lau, Lawrence C. M.
Ma, Li
Young, Alvin L.
Rong, Shi Song
Jhanji, Vishal
Brelen, Marten E.
Pang, Chi Pui
Chen, Li Jia
Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis
title Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis
title_full Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis
title_fullStr Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis
title_full_unstemmed Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis
title_short Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis
title_sort association of common variants in tcf4 and ptprg with fuchs' corneal dystrophy: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192317/
https://www.ncbi.nlm.nih.gov/pubmed/25299301
http://dx.doi.org/10.1371/journal.pone.0109142
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