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Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease
Epidemiological studies of neuromyelitis optica (NMO) in Jamaica are lacking. Here we reviewed the clinical records of 700 patients undergoing neurological evaluation at the Kingston Public Hospital, the largest tertiary institution in Jamaica over a 4 month period. We investigated the diagnostic ut...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192434/ https://www.ncbi.nlm.nih.gov/pubmed/25309712 http://dx.doi.org/10.4081/ni.2014.5395 |
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author | Sandy, Sherri Pittock, Sean J. Seemungal, Terence A.R. Ali, Amza |
author_facet | Sandy, Sherri Pittock, Sean J. Seemungal, Terence A.R. Ali, Amza |
author_sort | Sandy, Sherri |
collection | PubMed |
description | Epidemiological studies of neuromyelitis optica (NMO) in Jamaica are lacking. Here we reviewed the clinical records of 700 patients undergoing neurological evaluation at the Kingston Public Hospital, the largest tertiary institution in Jamaica over a 4 month period. We investigated the diagnostic utility of Aquaporin-4 ImmuneglobulinG (AQP4-IgG) testing in 36 consecutive patients with a diagnosis of an inflammatory demyelinating disorder (IDD) of the central nervous system (CNS). Patients were classified into 3 categories: i) NMO, n=10; ii) multiple sclerosis (MS), n=14 and iii) unclassified IDD (n=12). All sera were tested for AQP-IgG status by cell binding assay (Euroimmun). No MS cases were positive. Ninety per cent of NMO cases were positive. Four of 12 patients with unclassified IDD tested positive for AQP4-IgG. AQP4-IgG seropositivity was associated with a lower socioeconomic status, higher EDSS (P=0.04) and lower pulmonary function than the seronegative cases (P=0.007). Aquaporin-4 autoimmunity may account for a significant proportion of Jamaican CNS IDDs. |
format | Online Article Text |
id | pubmed-4192434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-41924342014-10-10 Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease Sandy, Sherri Pittock, Sean J. Seemungal, Terence A.R. Ali, Amza Neurol Int Brief Report Epidemiological studies of neuromyelitis optica (NMO) in Jamaica are lacking. Here we reviewed the clinical records of 700 patients undergoing neurological evaluation at the Kingston Public Hospital, the largest tertiary institution in Jamaica over a 4 month period. We investigated the diagnostic utility of Aquaporin-4 ImmuneglobulinG (AQP4-IgG) testing in 36 consecutive patients with a diagnosis of an inflammatory demyelinating disorder (IDD) of the central nervous system (CNS). Patients were classified into 3 categories: i) NMO, n=10; ii) multiple sclerosis (MS), n=14 and iii) unclassified IDD (n=12). All sera were tested for AQP-IgG status by cell binding assay (Euroimmun). No MS cases were positive. Ninety per cent of NMO cases were positive. Four of 12 patients with unclassified IDD tested positive for AQP4-IgG. AQP4-IgG seropositivity was associated with a lower socioeconomic status, higher EDSS (P=0.04) and lower pulmonary function than the seronegative cases (P=0.007). Aquaporin-4 autoimmunity may account for a significant proportion of Jamaican CNS IDDs. PAGEPress Publications, Pavia, Italy 2014-08-08 /pmc/articles/PMC4192434/ /pubmed/25309712 http://dx.doi.org/10.4081/ni.2014.5395 Text en ©Copyright S. Sandy et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Sandy, Sherri Pittock, Sean J. Seemungal, Terence A.R. Ali, Amza Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease |
title | Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease |
title_full | Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease |
title_fullStr | Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease |
title_full_unstemmed | Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease |
title_short | Aquaporin-4 Immuneglobulin G Testing in 36 Consecutive Jamaican Patients with Inflammatory Central Nervous System Demyelinating Disease |
title_sort | aquaporin-4 immuneglobulin g testing in 36 consecutive jamaican patients with inflammatory central nervous system demyelinating disease |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192434/ https://www.ncbi.nlm.nih.gov/pubmed/25309712 http://dx.doi.org/10.4081/ni.2014.5395 |
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