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Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease
Hyperuricemia is a frequent complication of chronic kidney disease (CKD). Febuxostat is a novel xanthine oxidase inhibitor that is metabolized by many metabolic pathways in the kidney and the liver. We performed a 1-year cohort study of 73 hyperuricemic patients who had an estimated glomerular filtr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer London
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192559/ https://www.ncbi.nlm.nih.gov/pubmed/25048744 http://dx.doi.org/10.1007/s10067-014-2745-5 |
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author | Tsuruta, Yuki Mochizuki, Toshio Moriyama, Takahito Itabashi, Mitsuyo Takei, Takashi Tsuchiya, Ken Nitta, Kosaku |
author_facet | Tsuruta, Yuki Mochizuki, Toshio Moriyama, Takahito Itabashi, Mitsuyo Takei, Takashi Tsuchiya, Ken Nitta, Kosaku |
author_sort | Tsuruta, Yuki |
collection | PubMed |
description | Hyperuricemia is a frequent complication of chronic kidney disease (CKD). Febuxostat is a novel xanthine oxidase inhibitor that is metabolized by many metabolic pathways in the kidney and the liver. We performed a 1-year cohort study of 73 hyperuricemic patients who had an estimated glomerular filtration rate (eGFR) below 45 ml/min and were being treated with urate-lowering therapy. In 51 patients, treatment was changed from allopurinol to febuxostat, and the other 22 patients were continued on allopurinol. The serum levels of uric acid (UA) level, creatinine, and other biochemical parameters were measured at baseline and after 3, 6, 9, and 12 months of treatment. The serum UA levels significantly decreased from 6.1 ± 1.0 to 5.7 ± 1.2 mg/dl in the febuxostat group and significantly increased from 6.2 ± 1.1 to 6.6 ± 1.1 mg/dl in the allopurinol group. The eGFR decreased 27.3 to 25.7 ml/min in the febuxostat group and from 26.1 to 19.9 ml/min in the allopurinol group. The switch from allopurinol to febuxostat was significantly associated with the changes in eGFR according to a multiple regression analysis (β = −0.22145, P < 0.05). Febuxostat reduced the serum UA levels and slowed the progression of renal disease in our CKD cohort in comparison with allopurinol. |
format | Online Article Text |
id | pubmed-4192559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer London |
record_format | MEDLINE/PubMed |
spelling | pubmed-41925592014-10-15 Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease Tsuruta, Yuki Mochizuki, Toshio Moriyama, Takahito Itabashi, Mitsuyo Takei, Takashi Tsuchiya, Ken Nitta, Kosaku Clin Rheumatol Original Article Hyperuricemia is a frequent complication of chronic kidney disease (CKD). Febuxostat is a novel xanthine oxidase inhibitor that is metabolized by many metabolic pathways in the kidney and the liver. We performed a 1-year cohort study of 73 hyperuricemic patients who had an estimated glomerular filtration rate (eGFR) below 45 ml/min and were being treated with urate-lowering therapy. In 51 patients, treatment was changed from allopurinol to febuxostat, and the other 22 patients were continued on allopurinol. The serum levels of uric acid (UA) level, creatinine, and other biochemical parameters were measured at baseline and after 3, 6, 9, and 12 months of treatment. The serum UA levels significantly decreased from 6.1 ± 1.0 to 5.7 ± 1.2 mg/dl in the febuxostat group and significantly increased from 6.2 ± 1.1 to 6.6 ± 1.1 mg/dl in the allopurinol group. The eGFR decreased 27.3 to 25.7 ml/min in the febuxostat group and from 26.1 to 19.9 ml/min in the allopurinol group. The switch from allopurinol to febuxostat was significantly associated with the changes in eGFR according to a multiple regression analysis (β = −0.22145, P < 0.05). Febuxostat reduced the serum UA levels and slowed the progression of renal disease in our CKD cohort in comparison with allopurinol. Springer London 2014-07-22 2014 /pmc/articles/PMC4192559/ /pubmed/25048744 http://dx.doi.org/10.1007/s10067-014-2745-5 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Tsuruta, Yuki Mochizuki, Toshio Moriyama, Takahito Itabashi, Mitsuyo Takei, Takashi Tsuchiya, Ken Nitta, Kosaku Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease |
title | Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease |
title_full | Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease |
title_fullStr | Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease |
title_full_unstemmed | Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease |
title_short | Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease |
title_sort | switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192559/ https://www.ncbi.nlm.nih.gov/pubmed/25048744 http://dx.doi.org/10.1007/s10067-014-2745-5 |
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