Cargando…

Topical treatment of oral lichen planus with anthocyanins

Background: Oxidative stress is involved in oral lichen planus (OLP) pathogenesis; meanwhile anthocyanins are natural antioxidants present in grapes skin. Objectives: The aim of this research was to verify the utility of anthocyanins, extracted from grapes skin, for the local treatment of oral liche...

Descripción completa

Detalles Bibliográficos
Autores principales: Rivarola de Gutierrez, Emilce, Di Fabio, Amanda, Salomón, Susana, Lanfranchi, Héctor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192568/
https://www.ncbi.nlm.nih.gov/pubmed/24880442
http://dx.doi.org/10.4317/medoral.19472
_version_ 1782338803774521344
author Rivarola de Gutierrez, Emilce
Di Fabio, Amanda
Salomón, Susana
Lanfranchi, Héctor
author_facet Rivarola de Gutierrez, Emilce
Di Fabio, Amanda
Salomón, Susana
Lanfranchi, Héctor
author_sort Rivarola de Gutierrez, Emilce
collection PubMed
description Background: Oxidative stress is involved in oral lichen planus (OLP) pathogenesis; meanwhile anthocyanins are natural antioxidants present in grapes skin. Objectives: The aim of this research was to verify the utility of anthocyanins, extracted from grapes skin, for the local treatment of oral lichen planus and to compare it with clobetasol propionate- neomycin -nystatin cream (CP-NN). Study Design: Prospective, non-randomized study, with control group. Fifty-two patients with OLP were included. We divided patients into two categories: erosive oral lichen planus (EOLP) and non erosive oral lichen planus (NEOLP). 38 had EOLP (17 cases and 21 controls) and 14 presented NEOLP types (9 cases and 5 controls).Cases received local treatment with anthocyanins from grapes and controls, were treated with CP-NN. The clinical evolution of patients was followed up during six months. Results: The patients had a therapeutic response with anthocyanins. This was better than CP-NN treatment for patients with EOLP, in improving the involvement score of the oral mucosa and in the morphometric study of the affected areas. In EOLP there were no statistically significant differences in: therapeutic response time, the evolution of pain, or the relapse rate between the two groups. With respect to the treatment of NEOLP there was improved pain relief in the group treated with anthocyanins. This was not observed with CP-NN. The resting analized variables showed no significant difference with both treatments. Conclusions: OLP has a favorable response to local treatment with anthocyanins from grapes. We found an equal to or better response than with CP-NN treatment. Many of our patients have systemic diseases, which may contraindicate the use of steroids. With regard to this particular group, the use of this natural antioxidant present in the diet is considered advantageous. Key words:Anthocyanins, antioxidants, chemoprevention, morphometry, oral lichen, oxidative stress.
format Online
Article
Text
id pubmed-4192568
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medicina Oral S.L.
record_format MEDLINE/PubMed
spelling pubmed-41925682014-10-20 Topical treatment of oral lichen planus with anthocyanins Rivarola de Gutierrez, Emilce Di Fabio, Amanda Salomón, Susana Lanfranchi, Héctor Med Oral Patol Oral Cir Bucal Research Background: Oxidative stress is involved in oral lichen planus (OLP) pathogenesis; meanwhile anthocyanins are natural antioxidants present in grapes skin. Objectives: The aim of this research was to verify the utility of anthocyanins, extracted from grapes skin, for the local treatment of oral lichen planus and to compare it with clobetasol propionate- neomycin -nystatin cream (CP-NN). Study Design: Prospective, non-randomized study, with control group. Fifty-two patients with OLP were included. We divided patients into two categories: erosive oral lichen planus (EOLP) and non erosive oral lichen planus (NEOLP). 38 had EOLP (17 cases and 21 controls) and 14 presented NEOLP types (9 cases and 5 controls).Cases received local treatment with anthocyanins from grapes and controls, were treated with CP-NN. The clinical evolution of patients was followed up during six months. Results: The patients had a therapeutic response with anthocyanins. This was better than CP-NN treatment for patients with EOLP, in improving the involvement score of the oral mucosa and in the morphometric study of the affected areas. In EOLP there were no statistically significant differences in: therapeutic response time, the evolution of pain, or the relapse rate between the two groups. With respect to the treatment of NEOLP there was improved pain relief in the group treated with anthocyanins. This was not observed with CP-NN. The resting analized variables showed no significant difference with both treatments. Conclusions: OLP has a favorable response to local treatment with anthocyanins from grapes. We found an equal to or better response than with CP-NN treatment. Many of our patients have systemic diseases, which may contraindicate the use of steroids. With regard to this particular group, the use of this natural antioxidant present in the diet is considered advantageous. Key words:Anthocyanins, antioxidants, chemoprevention, morphometry, oral lichen, oxidative stress. Medicina Oral S.L. 2014-09 2014-06-01 /pmc/articles/PMC4192568/ /pubmed/24880442 http://dx.doi.org/10.4317/medoral.19472 Text en Copyright: © 2014 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Rivarola de Gutierrez, Emilce
Di Fabio, Amanda
Salomón, Susana
Lanfranchi, Héctor
Topical treatment of oral lichen planus with anthocyanins
title Topical treatment of oral lichen planus with anthocyanins
title_full Topical treatment of oral lichen planus with anthocyanins
title_fullStr Topical treatment of oral lichen planus with anthocyanins
title_full_unstemmed Topical treatment of oral lichen planus with anthocyanins
title_short Topical treatment of oral lichen planus with anthocyanins
title_sort topical treatment of oral lichen planus with anthocyanins
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192568/
https://www.ncbi.nlm.nih.gov/pubmed/24880442
http://dx.doi.org/10.4317/medoral.19472
work_keys_str_mv AT rivaroladegutierrezemilce topicaltreatmentoforallichenplanuswithanthocyanins
AT difabioamanda topicaltreatmentoforallichenplanuswithanthocyanins
AT salomonsusana topicaltreatmentoforallichenplanuswithanthocyanins
AT lanfranchihector topicaltreatmentoforallichenplanuswithanthocyanins