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Silencing Bcl-2 Expression in Epithelial Cancer Cells Using “Smart” Particles

Short interfering RNA (siRNA) targeted against anti-apoptotic Bcl-2 protein proved to knockdown its expression and trigger cancer cell death. We used degradable, pH-sensitive, comb-like [P(EAA-co-BMA)-b-PNASI-g-P(HMA-co-TMAEMA)] polymer to condense anti-Bcl-2 siRNA into “smart” particles, which prov...

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Detalles Bibliográficos
Autores principales:	Lin, Yen-Ling, Jiang, Guohua, Zhang, Zhaocheng, Nör, Jacques E., ElSayed, Mohamed E. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192611/ https://www.ncbi.nlm.nih.gov/pubmed/25229941 http://dx.doi.org/10.3390/jfb5030167

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