Cargando…

Interactions between Calcium and Alpha-Synuclein in Neurodegeneration

In Parkinson’s disease and some atypical Parkinson’s syndromes, aggregation of the α-synuclein protein (α-syn) has been linked to neurodegeneration. Many triggers for pathological α-syn aggregation have been identified, including port-translational modifications, oxidative stress and raised metal io...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rcom-H’cheo-Gauthier, Alex, Goodwin, Jacob, Pountney, Dean L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192672/ https://www.ncbi.nlm.nih.gov/pubmed/25256602 http://dx.doi.org/10.3390/biom4030795

Ejemplares similares

Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
por: Rcom-H'cheo-Gauthier, Alexandre N., et al.
Publicado: (2016)

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
por: Okita, Yuho, et al.
Publicado: (2017)

Switching on Endogenous Metal Binding Proteins in Parkinson’s Disease
por: McLeary, Fleur A., et al.
Publicado: (2019)

Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy
por: Valdinocci, Dario, et al.
Publicado: (2018)

Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity
por: Vijayakumaran, Shamini, et al.
Publicado: (2015)

Alpha Synuclein: Neurodegeneration and Inflammation
por: Forloni, Gianluigi
Publicado: (2023)

Alpha-synuclein and tau: teammates in neurodegeneration?
por: Moussaud, Simon, et al.
Publicado: (2014)

Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?
por: Post, Michael R., et al.
Publicado: (2018)

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
por: Ghiglieri, Veronica, et al.
Publicado: (2018)

Potential Modes of Intercellular α-Synuclein Transmission
por: Valdinocci, Dario, et al.
Publicado: (2017)

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s Disease
por: Xu, Shengli, et al.
Publicado: (2015)

Extracellular Alpha-Synuclein Promotes a Neuroinhibitory Secretory Phenotype in Astrocytes
por: Di Marco Vieira, Bruno, et al.
Publicado: (2020)

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration
por: Van Rompuy, Anne-Sophie, et al.
Publicado: (2015)

Investigating key factors underlying neurodegeneration linked to alpha‐synuclein spread
por: Pang, Cindy C. C., et al.
Publicado: (2022)

Alpha-synuclein structure, functions, and interactions
por: Emamzadeh, Fatemeh Nouri
Publicado: (2016)

Neurodegeneration and the ordered assembly of α-synuclein
por: Spillantini, Maria Grazia, et al.
Publicado: (2017)

Interaction of Mitochondrial Calcium and ROS in Neurodegeneration
por: Baev, Artyom Y., et al.
Publicado: (2022)

Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson’s Disease
por: Boag, Matthew K., et al.
Publicado: (2022)

The Membrane Interaction of Alpha-Synuclein
por: Liu, Cencen, et al.
Publicado: (2021)

α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration
por: Fecchio, Chiara, et al.
Publicado: (2018)

The Role of Alpha-Synuclein Autoantibodies in the Induction of Brain Inflammation and Neurodegeneration in Aged Humans
por: Pandey, Manoj Kumar
Publicado: (2022)

Subcellular localization of alpha-synuclein aggregates and their interaction with membranes
por: Miraglia, Fabiana, et al.
Publicado: (2018)

Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
por: Calabresi, Paolo, et al.
Publicado: (2023)

The Interplay between Alpha-Synuclein Clearance and Spreading
por: Lopes da Fonseca, Tomás, et al.
Publicado: (2015)

Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease
por: Wang, Ting, et al.
Publicado: (2015)

Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration
por: Wang, Junling, et al.
Publicado: (2017)

Temporal Evolution of Inflammation and Neurodegeneration With Alpha-Synuclein Propagation in Parkinson's Disease Mouse Model
por: Lai, Thuy Thi, et al.
Publicado: (2021)

Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson’s Disease
por: Jewett, Michael, et al.
Publicado: (2018)

Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation
por: Betzer, Cristine, et al.
Publicado: (2018)

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
por: Vieira, Bruno Di Marco, et al.
Publicado: (2015)

Gastrointestinal Immunity and Alpha-Synuclein
por: Barbut, Denise, et al.
Publicado: (2019)

Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein
por: Krasnoslobodtsev, Alexey V., et al.
Publicado: (2012)

Calcium signaling in neurodegeneration
por: Marambaud, Philippe, et al.
Publicado: (2009)

Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease
por: Williams, Gregory P., et al.
Publicado: (2018)

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression
por: Wang, Yong, et al.
Publicado: (2020)

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein
por: Koprich, James B., et al.
Publicado: (2011)

Alpha-Synuclein—Nanoparticle Interactions: Understanding, Controlling and Exploiting Conformational Plasticity
por: D’Onofrio, Mariapina, et al.
Publicado: (2020)

Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification
por: Sugeno, Naoto, et al.
Publicado: (2023)

Editorial: Synergistic interactions between exosomes and tunneling nanotubes in long-range intercellular transfer
por: Nath, Sangeeta, et al.
Publicado: (2023)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hgk91jk6gndp63c4p92334fji6