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Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors

Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal gangl...

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Detalles Bibliográficos
Autores principales: Apara, Akintomide, Goldberg, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192940/
https://www.ncbi.nlm.nih.gov/pubmed/25317150
http://dx.doi.org/10.4103/1673-5374.139454
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author Apara, Akintomide
Goldberg, Jeffrey L.
author_facet Apara, Akintomide
Goldberg, Jeffrey L.
author_sort Apara, Akintomide
collection PubMed
description Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hippocampal and cortical neurons. With at least 15 of 17 KLF family members expressed in neurons and at least 5 structurally unique subfamilies, it is important to determine how this complex family functions in neurons to regulate the intricate genetic programs of axon growth and regeneration. By characterizing the molecular mechanisms of the KLF family in the nervous system, including binding partners and gene targets, and comparing them to defined mechanisms defined outside the nervous system, we may better understand how KLFs regulate neurite growth and axon regeneration.
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spelling pubmed-41929402014-10-14 Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors Apara, Akintomide Goldberg, Jeffrey L. Neural Regen Res Invited Review Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hippocampal and cortical neurons. With at least 15 of 17 KLF family members expressed in neurons and at least 5 structurally unique subfamilies, it is important to determine how this complex family functions in neurons to regulate the intricate genetic programs of axon growth and regeneration. By characterizing the molecular mechanisms of the KLF family in the nervous system, including binding partners and gene targets, and comparing them to defined mechanisms defined outside the nervous system, we may better understand how KLFs regulate neurite growth and axon regeneration. Medknow Publications & Media Pvt Ltd 2014-08-01 /pmc/articles/PMC4192940/ /pubmed/25317150 http://dx.doi.org/10.4103/1673-5374.139454 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Apara, Akintomide
Goldberg, Jeffrey L.
Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors
title Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors
title_full Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors
title_fullStr Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors
title_full_unstemmed Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors
title_short Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors
title_sort molecular mechanisms of the suppression of axon regeneration by klf transcription factors
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192940/
https://www.ncbi.nlm.nih.gov/pubmed/25317150
http://dx.doi.org/10.4103/1673-5374.139454
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