Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury

Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized th...

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Autores principales: Dong, Yuzhen, Yang, Libin, Yang, Lin, Zhao, Hongxing, Zhang, Chao, Wu, Dapeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research and Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192969/
https://www.ncbi.nlm.nih.gov/pubmed/25317169
http://dx.doi.org/10.4103/1673-5374.139478
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author Dong, Yuzhen
Yang, Libin
Yang, Lin
Zhao, Hongxing
Zhang, Chao
Wu, Dapeng
author_facet Dong, Yuzhen
Yang, Libin
Yang, Lin
Zhao, Hongxing
Zhang, Chao
Wu, Dapeng
author_sort Dong, Yuzhen
collection PubMed
description Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury.
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spelling pubmed-41929692014-10-14 Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury Dong, Yuzhen Yang, Libin Yang, Lin Zhao, Hongxing Zhang, Chao Wu, Dapeng Neural Regen Res Research and Report Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury. Medknow Publications & Media Pvt Ltd 2014-08-15 /pmc/articles/PMC4192969/ /pubmed/25317169 http://dx.doi.org/10.4103/1673-5374.139478 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Dong, Yuzhen
Yang, Libin
Yang, Lin
Zhao, Hongxing
Zhang, Chao
Wu, Dapeng
Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury
title Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury
title_full Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury
title_fullStr Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury
title_full_unstemmed Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury
title_short Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury
title_sort transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192969/
https://www.ncbi.nlm.nih.gov/pubmed/25317169
http://dx.doi.org/10.4103/1673-5374.139478
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