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A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome

Human artificial chromosomes (HACs) are gene-delivery vectors suitable for introducing large DNA fragments into mammalian cells. Although a HAC theoretically incorporates multiple gene expression cassettes of unlimited DNA size, its application has been limited because the conventional gene-loading...

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Detalles Bibliográficos
Autores principales:	Suzuki, Teruhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Hara, Takahiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193884/ https://www.ncbi.nlm.nih.gov/pubmed/25303219 http://dx.doi.org/10.1371/journal.pone.0110404

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