The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

BACKGROUND: The p38α mitogen-activated protein kinase (MAPK) is a well-characterized intracellular kinase involved in the overproduction of proinflammatory cytokines from glia. As such, p38α appears to be a promising therapeutic target for neurodegenerative diseases associated with neuroinflammation...

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Detalles Bibliográficos
Autores principales: Bachstetter, Adam D, Xing, Bin, Van Eldik, Linda J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193976/
https://www.ncbi.nlm.nih.gov/pubmed/25297465
http://dx.doi.org/10.1186/s12974-014-0175-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193976/
https://www.ncbi.nlm.nih.gov/pubmed/25297465
http://dx.doi.org/10.1186/s12974-014-0175-6

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