β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network

INTRODUCTION: Recent histopathological studies have shown that neurodegenerative processes in Alzheimer’s and Parkinson’s Disease develop along neuronal networks and that hallmarks could propagate trans-synaptically through neuronal pathways. The underlying molecular mechanisms are still unknown, an...

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Detalles Bibliográficos
Autores principales: Deleglise, Bérangère, Magnifico, Sebastien, Duplus, Eric, Vaur, Pauline, Soubeyre, Vanessa, Belle, Morgane, Vignes, Maeva, Viovy, Jean-Louis, Jacotot, Etienne, Peyrin, Jean-Michel, Brugg, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193981/
https://www.ncbi.nlm.nih.gov/pubmed/25253021
http://dx.doi.org/10.1186/s40478-014-0145-3

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