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The Mysterious Ways of ErbB2/HER2 Trafficking

The EGFR- or ErbB-family of receptor tyrosine kinases consists of EGFR/ErbB1, ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4. Receptor activation and downstream signaling are generally initiated upon ligand-induced receptor homo- or heterodimerization at the plasma membrane, and endocytosis and intracellular...

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Detalles Bibliográficos
Autores principales: Bertelsen, Vibeke, Stang, Espen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194043/
https://www.ncbi.nlm.nih.gov/pubmed/25102001
http://dx.doi.org/10.3390/membranes4030424