Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer

Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible factor 1A (HIF1A) is a major regulator of this process, but its activation u...

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Detalles Bibliográficos
Autores principales: Zecchini, Vincent, Madhu, Basetti, Russell, Roslin, Pértega-Gomes, Nelma, Warren, Anne, Gaude, Edoardo, Borlido, Joana, Stark, Rory, Ireland-Zecchini, Heather, Rao, Roheet, Scott, Helen, Boren, Joan, Massie, Charlie, Asim, Mohammad, Brindle, Kevin, Griffiths, John, Frezza, Christian, Neal, David E, Mills, Ian G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194125/
https://www.ncbi.nlm.nih.gov/pubmed/24837709
http://dx.doi.org/10.15252/embj.201386874

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