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Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience

PURPOSE: We reviewed treatment outcomes and prognostic factors for patients with salivary ductal carcinoma (SDC) treated with surgery and postoperative radiotherapy from 2005 to 2012. MATERIALS AND METHODS: A total of 16 patients were identified and 15 eligible patients were included in analysis. Me...

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Autores principales: Kim, Tae Hyung, Kim, Mi Sun, Choi, Seo Hee, Suh, Yang Gun, Koh, Yoon Woo, Kim, Se Hun, Choi, Eun Chang, Keum, Ki Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194294/
https://www.ncbi.nlm.nih.gov/pubmed/25324983
http://dx.doi.org/10.3857/roj.2014.32.3.125
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author Kim, Tae Hyung
Kim, Mi Sun
Choi, Seo Hee
Suh, Yang Gun
Koh, Yoon Woo
Kim, Se Hun
Choi, Eun Chang
Keum, Ki Chang
author_facet Kim, Tae Hyung
Kim, Mi Sun
Choi, Seo Hee
Suh, Yang Gun
Koh, Yoon Woo
Kim, Se Hun
Choi, Eun Chang
Keum, Ki Chang
author_sort Kim, Tae Hyung
collection PubMed
description PURPOSE: We reviewed treatment outcomes and prognostic factors for patients with salivary ductal carcinoma (SDC) treated with surgery and postoperative radiotherapy from 2005 to 2012. MATERIALS AND METHODS: A total of 16 patients were identified and 15 eligible patients were included in analysis. Median age was 61 years (range, 40 to 71 years) and 12 patients (80%) were men. Twelve patients (80%) had a tumor in the parotid gland, 9 (60%) had T3 or T4 disease, and 9 (60%) had positive nodal disease. All patients underwent surgery and postoperative radiotherapy. Postoperative radiotherapy was delivered using 3-dimensional conformal radiotherapy or intensity-modulated radiotherapy. Locoregional failure-free survival (LRFFS), distant failure-free survival (DFFS), progression-free survival (PFS), and overall survival (OS) were calculated using the Kaplan-Meier method. Differences in survival based on risk factors were tested using a log-rank test. RESULTS: Median total radiotherapy dose was 60 Gy (range, 52.5 to 63.6 Gy). Four patients received concurrent weekly chemotherapy with cisplatin. Among 10 patients who underwent surgery with neck dissection, 7 received modified radical neck dissection. With a median follow-up time of 38 months (range, 24 to 105 months), 4-year rates were 86% for LRFFS, 51% for DFFS, 46% for PFS, and 93% for OS. Local failure was observed in 2 patients (13%), and distant failure was observed in 7 (47%). The lung was the most common involved site of distant metastasis. CONCLUSION: Surgery and postoperative radiotherapy in SDC patients resulted in good local control, but high distant metastasis remained a major challenge.
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spelling pubmed-41942942014-10-16 Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience Kim, Tae Hyung Kim, Mi Sun Choi, Seo Hee Suh, Yang Gun Koh, Yoon Woo Kim, Se Hun Choi, Eun Chang Keum, Ki Chang Radiat Oncol J Original Article PURPOSE: We reviewed treatment outcomes and prognostic factors for patients with salivary ductal carcinoma (SDC) treated with surgery and postoperative radiotherapy from 2005 to 2012. MATERIALS AND METHODS: A total of 16 patients were identified and 15 eligible patients were included in analysis. Median age was 61 years (range, 40 to 71 years) and 12 patients (80%) were men. Twelve patients (80%) had a tumor in the parotid gland, 9 (60%) had T3 or T4 disease, and 9 (60%) had positive nodal disease. All patients underwent surgery and postoperative radiotherapy. Postoperative radiotherapy was delivered using 3-dimensional conformal radiotherapy or intensity-modulated radiotherapy. Locoregional failure-free survival (LRFFS), distant failure-free survival (DFFS), progression-free survival (PFS), and overall survival (OS) were calculated using the Kaplan-Meier method. Differences in survival based on risk factors were tested using a log-rank test. RESULTS: Median total radiotherapy dose was 60 Gy (range, 52.5 to 63.6 Gy). Four patients received concurrent weekly chemotherapy with cisplatin. Among 10 patients who underwent surgery with neck dissection, 7 received modified radical neck dissection. With a median follow-up time of 38 months (range, 24 to 105 months), 4-year rates were 86% for LRFFS, 51% for DFFS, 46% for PFS, and 93% for OS. Local failure was observed in 2 patients (13%), and distant failure was observed in 7 (47%). The lung was the most common involved site of distant metastasis. CONCLUSION: Surgery and postoperative radiotherapy in SDC patients resulted in good local control, but high distant metastasis remained a major challenge. The Korean Society for Radiation Oncology 2014-09 2014-09-30 /pmc/articles/PMC4194294/ /pubmed/25324983 http://dx.doi.org/10.3857/roj.2014.32.3.125 Text en Copyright © 2014. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Tae Hyung
Kim, Mi Sun
Choi, Seo Hee
Suh, Yang Gun
Koh, Yoon Woo
Kim, Se Hun
Choi, Eun Chang
Keum, Ki Chang
Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience
title Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience
title_full Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience
title_fullStr Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience
title_full_unstemmed Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience
title_short Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience
title_sort postoperative radiotherapy in salivary ductal carcinoma: a single institution experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194294/
https://www.ncbi.nlm.nih.gov/pubmed/25324983
http://dx.doi.org/10.3857/roj.2014.32.3.125
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