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The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study

PURPOSE: This study was designed to evaluate the efficacy and safety of topically applied recombinant human epidermal growth factor (rhEGF) for the prevention of radiation-induced dermatitis in cancer patients. MATERIALS AND METHODS: From December 2010 to April 2012, a total of 1,172 cancer patients...

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Autores principales: Kang, Hyun-Cheol, Ahn, Seung-Do, Choi, Doo-Ho, Kang, Min Kyu, Chung, Woong-Ki, Wu, Hong-Gyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194298/
https://www.ncbi.nlm.nih.gov/pubmed/25324987
http://dx.doi.org/10.3857/roj.2014.32.3.156
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author Kang, Hyun-Cheol
Ahn, Seung-Do
Choi, Doo-Ho
Kang, Min Kyu
Chung, Woong-Ki
Wu, Hong-Gyun
author_facet Kang, Hyun-Cheol
Ahn, Seung-Do
Choi, Doo-Ho
Kang, Min Kyu
Chung, Woong-Ki
Wu, Hong-Gyun
author_sort Kang, Hyun-Cheol
collection PubMed
description PURPOSE: This study was designed to evaluate the efficacy and safety of topically applied recombinant human epidermal growth factor (rhEGF) for the prevention of radiation-induced dermatitis in cancer patients. MATERIALS AND METHODS: From December 2010 to April 2012, a total of 1,172 cancer patients who received radiotherapy (RT) of more than 50 Gy were prospectively enrolled and treated with EGF-based cream. An acute skin reaction classified according to the Radiation Therapy Oncology Group 6-point rating scale was the primary end point and we also assessed the occurrence of edema, dry skin, or pruritus. RESULTS: The percentage of radiation dermatitis with maximum grade 0 and grade 1 was 19% and 58% at the time of 50 Gy, and it became 29% and 47% after completion of planned RT. This increment was observed only in breast cancer patients (from 18%/62% to 32%/49%). Adverse events related to the EGF-based cream developed in 49 patients (4%) with mild erythema the most common. Skin toxicity grade >2 was observed in 5% of the patients. Edema, dry skin, and pruritus grade ≥3 developed in 9%, 9%, and 1% of the patients, respectively. CONCLUSION: Prophylactic use of an EGF-based cream is effective in preventing radiation dermatitis with tolerable toxicity. Further studies comparing EGF cream with other topical agents may be necessary.
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spelling pubmed-41942982014-10-16 The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study Kang, Hyun-Cheol Ahn, Seung-Do Choi, Doo-Ho Kang, Min Kyu Chung, Woong-Ki Wu, Hong-Gyun Radiat Oncol J Original Article PURPOSE: This study was designed to evaluate the efficacy and safety of topically applied recombinant human epidermal growth factor (rhEGF) for the prevention of radiation-induced dermatitis in cancer patients. MATERIALS AND METHODS: From December 2010 to April 2012, a total of 1,172 cancer patients who received radiotherapy (RT) of more than 50 Gy were prospectively enrolled and treated with EGF-based cream. An acute skin reaction classified according to the Radiation Therapy Oncology Group 6-point rating scale was the primary end point and we also assessed the occurrence of edema, dry skin, or pruritus. RESULTS: The percentage of radiation dermatitis with maximum grade 0 and grade 1 was 19% and 58% at the time of 50 Gy, and it became 29% and 47% after completion of planned RT. This increment was observed only in breast cancer patients (from 18%/62% to 32%/49%). Adverse events related to the EGF-based cream developed in 49 patients (4%) with mild erythema the most common. Skin toxicity grade >2 was observed in 5% of the patients. Edema, dry skin, and pruritus grade ≥3 developed in 9%, 9%, and 1% of the patients, respectively. CONCLUSION: Prophylactic use of an EGF-based cream is effective in preventing radiation dermatitis with tolerable toxicity. Further studies comparing EGF cream with other topical agents may be necessary. The Korean Society for Radiation Oncology 2014-09 2014-09-30 /pmc/articles/PMC4194298/ /pubmed/25324987 http://dx.doi.org/10.3857/roj.2014.32.3.156 Text en Copyright © 2014. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kang, Hyun-Cheol
Ahn, Seung-Do
Choi, Doo-Ho
Kang, Min Kyu
Chung, Woong-Ki
Wu, Hong-Gyun
The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
title The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
title_full The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
title_fullStr The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
title_full_unstemmed The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
title_short The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
title_sort safety and efficacy of egf-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194298/
https://www.ncbi.nlm.nih.gov/pubmed/25324987
http://dx.doi.org/10.3857/roj.2014.32.3.156
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