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Cognitive processing of cluster headache patients: evidence from event-related potentials

BACKGROUND: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in...

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Autores principales: Wang, Rongfei, Dong, Zhao, Chen, Xiaoyan, Liu, Ruozhuo, Zhang, Mingjie, Wu, Jinglong, Yu, Shengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194445/
https://www.ncbi.nlm.nih.gov/pubmed/25277954
http://dx.doi.org/10.1186/1129-2377-15-66
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author Wang, Rongfei
Dong, Zhao
Chen, Xiaoyan
Liu, Ruozhuo
Zhang, Mingjie
Wu, Jinglong
Yu, Shengyuan
author_facet Wang, Rongfei
Dong, Zhao
Chen, Xiaoyan
Liu, Ruozhuo
Zhang, Mingjie
Wu, Jinglong
Yu, Shengyuan
author_sort Wang, Rongfei
collection PubMed
description BACKGROUND: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central regions might be more important. Event-related potentials confer advantages in the functional evaluation of the cortex, but few studies thus far have employed this method in cluster headache. METHODS: Seventeen cluster patients (15 males; mean age = 35.4 years) and 15 age-matched healthy participants (13 males; mean age = 34.6 years) were recruited. A visual oddball paradigm was employed to analyze target processing using event-related potentials. We investigated the P3/P3d components in the experiment. RESULTS: P3/P3d amplitudes were decreased in CH patients (P3, 3.82 μV; P3d, 5.8 μV) compared with controls (P3, 7.28 μV; P3d, 8.95 μV), F(1,30) = 4.919, p < 0.05, η2 = 0.141 for P3 and F(1,30) = 8.514, p < 0.05, η2 = 0.221 for P3d, respectively). Moreover, the amplitudes of P3/P3d were no significantl difference in the side of pain as compared to contralateral one (p > 0.05). CONCLUSIONS: These results provide evidence of dysfunction in the cognitive processing of CH patients, which may also contribute to the pathophysiology of CH.
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spelling pubmed-41944452014-10-13 Cognitive processing of cluster headache patients: evidence from event-related potentials Wang, Rongfei Dong, Zhao Chen, Xiaoyan Liu, Ruozhuo Zhang, Mingjie Wu, Jinglong Yu, Shengyuan J Headache Pain Research Article BACKGROUND: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central regions might be more important. Event-related potentials confer advantages in the functional evaluation of the cortex, but few studies thus far have employed this method in cluster headache. METHODS: Seventeen cluster patients (15 males; mean age = 35.4 years) and 15 age-matched healthy participants (13 males; mean age = 34.6 years) were recruited. A visual oddball paradigm was employed to analyze target processing using event-related potentials. We investigated the P3/P3d components in the experiment. RESULTS: P3/P3d amplitudes were decreased in CH patients (P3, 3.82 μV; P3d, 5.8 μV) compared with controls (P3, 7.28 μV; P3d, 8.95 μV), F(1,30) = 4.919, p < 0.05, η2 = 0.141 for P3 and F(1,30) = 8.514, p < 0.05, η2 = 0.221 for P3d, respectively). Moreover, the amplitudes of P3/P3d were no significantl difference in the side of pain as compared to contralateral one (p > 0.05). CONCLUSIONS: These results provide evidence of dysfunction in the cognitive processing of CH patients, which may also contribute to the pathophysiology of CH. Springer 2014 2014-10-02 /pmc/articles/PMC4194445/ /pubmed/25277954 http://dx.doi.org/10.1186/1129-2377-15-66 Text en Copyright © 2014 Wang et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Wang, Rongfei
Dong, Zhao
Chen, Xiaoyan
Liu, Ruozhuo
Zhang, Mingjie
Wu, Jinglong
Yu, Shengyuan
Cognitive processing of cluster headache patients: evidence from event-related potentials
title Cognitive processing of cluster headache patients: evidence from event-related potentials
title_full Cognitive processing of cluster headache patients: evidence from event-related potentials
title_fullStr Cognitive processing of cluster headache patients: evidence from event-related potentials
title_full_unstemmed Cognitive processing of cluster headache patients: evidence from event-related potentials
title_short Cognitive processing of cluster headache patients: evidence from event-related potentials
title_sort cognitive processing of cluster headache patients: evidence from event-related potentials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194445/
https://www.ncbi.nlm.nih.gov/pubmed/25277954
http://dx.doi.org/10.1186/1129-2377-15-66
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