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Cognitive processing of cluster headache patients: evidence from event-related potentials
BACKGROUND: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194445/ https://www.ncbi.nlm.nih.gov/pubmed/25277954 http://dx.doi.org/10.1186/1129-2377-15-66 |
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author | Wang, Rongfei Dong, Zhao Chen, Xiaoyan Liu, Ruozhuo Zhang, Mingjie Wu, Jinglong Yu, Shengyuan |
author_facet | Wang, Rongfei Dong, Zhao Chen, Xiaoyan Liu, Ruozhuo Zhang, Mingjie Wu, Jinglong Yu, Shengyuan |
author_sort | Wang, Rongfei |
collection | PubMed |
description | BACKGROUND: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central regions might be more important. Event-related potentials confer advantages in the functional evaluation of the cortex, but few studies thus far have employed this method in cluster headache. METHODS: Seventeen cluster patients (15 males; mean age = 35.4 years) and 15 age-matched healthy participants (13 males; mean age = 34.6 years) were recruited. A visual oddball paradigm was employed to analyze target processing using event-related potentials. We investigated the P3/P3d components in the experiment. RESULTS: P3/P3d amplitudes were decreased in CH patients (P3, 3.82 μV; P3d, 5.8 μV) compared with controls (P3, 7.28 μV; P3d, 8.95 μV), F(1,30) = 4.919, p < 0.05, η2 = 0.141 for P3 and F(1,30) = 8.514, p < 0.05, η2 = 0.221 for P3d, respectively). Moreover, the amplitudes of P3/P3d were no significantl difference in the side of pain as compared to contralateral one (p > 0.05). CONCLUSIONS: These results provide evidence of dysfunction in the cognitive processing of CH patients, which may also contribute to the pathophysiology of CH. |
format | Online Article Text |
id | pubmed-4194445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-41944452014-10-13 Cognitive processing of cluster headache patients: evidence from event-related potentials Wang, Rongfei Dong, Zhao Chen, Xiaoyan Liu, Ruozhuo Zhang, Mingjie Wu, Jinglong Yu, Shengyuan J Headache Pain Research Article BACKGROUND: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central regions might be more important. Event-related potentials confer advantages in the functional evaluation of the cortex, but few studies thus far have employed this method in cluster headache. METHODS: Seventeen cluster patients (15 males; mean age = 35.4 years) and 15 age-matched healthy participants (13 males; mean age = 34.6 years) were recruited. A visual oddball paradigm was employed to analyze target processing using event-related potentials. We investigated the P3/P3d components in the experiment. RESULTS: P3/P3d amplitudes were decreased in CH patients (P3, 3.82 μV; P3d, 5.8 μV) compared with controls (P3, 7.28 μV; P3d, 8.95 μV), F(1,30) = 4.919, p < 0.05, η2 = 0.141 for P3 and F(1,30) = 8.514, p < 0.05, η2 = 0.221 for P3d, respectively). Moreover, the amplitudes of P3/P3d were no significantl difference in the side of pain as compared to contralateral one (p > 0.05). CONCLUSIONS: These results provide evidence of dysfunction in the cognitive processing of CH patients, which may also contribute to the pathophysiology of CH. Springer 2014 2014-10-02 /pmc/articles/PMC4194445/ /pubmed/25277954 http://dx.doi.org/10.1186/1129-2377-15-66 Text en Copyright © 2014 Wang et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Article Wang, Rongfei Dong, Zhao Chen, Xiaoyan Liu, Ruozhuo Zhang, Mingjie Wu, Jinglong Yu, Shengyuan Cognitive processing of cluster headache patients: evidence from event-related potentials |
title | Cognitive processing of cluster headache patients: evidence from event-related potentials |
title_full | Cognitive processing of cluster headache patients: evidence from event-related potentials |
title_fullStr | Cognitive processing of cluster headache patients: evidence from event-related potentials |
title_full_unstemmed | Cognitive processing of cluster headache patients: evidence from event-related potentials |
title_short | Cognitive processing of cluster headache patients: evidence from event-related potentials |
title_sort | cognitive processing of cluster headache patients: evidence from event-related potentials |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194445/ https://www.ncbi.nlm.nih.gov/pubmed/25277954 http://dx.doi.org/10.1186/1129-2377-15-66 |
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