Cargando…

Bisphosphonate drug holidays: Can we recommend currently?

Bisphosphonates (BP) are the mainstay of treatment for osteoporosis. Subtrochanteric or diaphyseal fractures have been reported with long term use of BP, which raised world-wide debate on two aspects, i.e., for how long the BP is to be given and potential advantages/role of BP drug holidays. BP accu...

Descripción completa

Detalles Bibliográficos
Autores principales: Tandon, Vishal R., Sharma, Sudhaa, Mahajan, Annil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195182/
https://www.ncbi.nlm.nih.gov/pubmed/25316995
http://dx.doi.org/10.4103/0976-7800.141186
_version_ 1782339272622211072
author Tandon, Vishal R.
Sharma, Sudhaa
Mahajan, Annil
author_facet Tandon, Vishal R.
Sharma, Sudhaa
Mahajan, Annil
author_sort Tandon, Vishal R.
collection PubMed
description Bisphosphonates (BP) are the mainstay of treatment for osteoporosis. Subtrochanteric or diaphyseal fractures have been reported with long term use of BP, which raised world-wide debate on two aspects, i.e., for how long the BP is to be given and potential advantages/role of BP drug holidays. BP accumulates in bone with some persistent protective effect after therapy is stopped endorses the concept. Theoretically, a drug holiday may be a considerable option to decrease risks of BP, which continuing the protection from fractures but the level of evidence and data supporting the concept of drug holidays is a week. Hence, no specific recommendations are available on BP drug holidays from major available treatment guidelines on postmenopausal osteoporosis. Hence, before it is recommended it requires more robust research in this field.
format Online
Article
Text
id pubmed-4195182
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-41951822014-10-14 Bisphosphonate drug holidays: Can we recommend currently? Tandon, Vishal R. Sharma, Sudhaa Mahajan, Annil J Midlife Health Review Article Bisphosphonates (BP) are the mainstay of treatment for osteoporosis. Subtrochanteric or diaphyseal fractures have been reported with long term use of BP, which raised world-wide debate on two aspects, i.e., for how long the BP is to be given and potential advantages/role of BP drug holidays. BP accumulates in bone with some persistent protective effect after therapy is stopped endorses the concept. Theoretically, a drug holiday may be a considerable option to decrease risks of BP, which continuing the protection from fractures but the level of evidence and data supporting the concept of drug holidays is a week. Hence, no specific recommendations are available on BP drug holidays from major available treatment guidelines on postmenopausal osteoporosis. Hence, before it is recommended it requires more robust research in this field. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4195182/ /pubmed/25316995 http://dx.doi.org/10.4103/0976-7800.141186 Text en Copyright: © Journal of Mid-life Health http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tandon, Vishal R.
Sharma, Sudhaa
Mahajan, Annil
Bisphosphonate drug holidays: Can we recommend currently?
title Bisphosphonate drug holidays: Can we recommend currently?
title_full Bisphosphonate drug holidays: Can we recommend currently?
title_fullStr Bisphosphonate drug holidays: Can we recommend currently?
title_full_unstemmed Bisphosphonate drug holidays: Can we recommend currently?
title_short Bisphosphonate drug holidays: Can we recommend currently?
title_sort bisphosphonate drug holidays: can we recommend currently?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195182/
https://www.ncbi.nlm.nih.gov/pubmed/25316995
http://dx.doi.org/10.4103/0976-7800.141186
work_keys_str_mv AT tandonvishalr bisphosphonatedrugholidayscanwerecommendcurrently
AT sharmasudhaa bisphosphonatedrugholidayscanwerecommendcurrently
AT mahajanannil bisphosphonatedrugholidayscanwerecommendcurrently