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Role of Polymeric Endosomolytic Agents in Gene Transfection: A Comparative Study of Poly(l-lysine) Grafted with Monomeric l-Histidine Analogue and Poly(l-histidine)

[Image: see text] Endosomal entrapment is one of the main barriers that must be overcome for efficient gene expression along with cell internalization, DNA release, and nuclear import. Introducing pH-sensitive ionizable groups into the polycationic polymers to increase gene transfer efficiency has p...

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Detalles Bibliográficos
Autores principales:	Hwang, Hee Sook, Hu, Jun, Na, Kun, Bae, You Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195522/ https://www.ncbi.nlm.nih.gov/pubmed/25144273 http://dx.doi.org/10.1021/bm500843r

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