MRE11-Deficiency Associated with Improved Long-Term Disease Free Survival and Overall Survival in a Subset of Stage III Colon Cancer Patients in Randomized CALGB 89803 Trial

PURPOSE: Colon cancers deficient in mismatch repair (MMR) may exhibit diminished expression of the DNA repair gene, MRE11, as a consequence of contraction of a T(11) mononucleotide tract. This study investigated MRE11 status and its association with prognosis, survival and drug response in patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Pavelitz, Thomas, Renfro, Lindsay, Foster, Nathan R., Caracol, Amber, Welsch, Piri, Lao, Victoria Valinluck, Grady, William B., Niedzwiecki, Donna, Saltz, Leonard B., Bertagnolli, Monica M., Goldberg, Richard M., Rabinovitch, Peter S., Emond, Mary, Monnat, Raymond J., Maizels, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195600/
https://www.ncbi.nlm.nih.gov/pubmed/25310185
http://dx.doi.org/10.1371/journal.pone.0108483

Ejemplares similares

Ejemplares similares