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Action Potential-Evoked Calcium Release Is Impaired in Single Skeletal Muscle Fibers from Heart Failure Patients
BACKGROUND: Exercise intolerance in chronic heart failure (HF) has been attributed to abnormalities of the skeletal muscles. Muscle function depends on intact excitation-contraction coupling (ECC), but ECC studies in HF models have been inconclusive, due to deficiencies in the animal models and tool...
Autores principales: | DiFranco, Marino, Quiñonez, Marbella, Shieh, Perry, Fonarow, Gregg C., Cruz, Daniel, Deng, Mario C., Vergara, Julio L., Middlekauff, Holly R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195605/ https://www.ncbi.nlm.nih.gov/pubmed/25310188 http://dx.doi.org/10.1371/journal.pone.0109309 |
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