Cargando…

Inhibition Effect of a Custom Peptide on Lung Tumors

Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids....

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Chih-Yu, Huang, Hsuan-Yu, Forrest, Michael D., Pan, Yun-Ru, Wu, Wei-Jen, Chen, Hueih-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195615/
https://www.ncbi.nlm.nih.gov/pubmed/25310698
http://dx.doi.org/10.1371/journal.pone.0109174
_version_ 1782339332404674560
author Huang, Chih-Yu
Huang, Hsuan-Yu
Forrest, Michael D.
Pan, Yun-Ru
Wu, Wei-Jen
Chen, Hueih-Min
author_facet Huang, Chih-Yu
Huang, Hsuan-Yu
Forrest, Michael D.
Pan, Yun-Ru
Wu, Wei-Jen
Chen, Hueih-Min
author_sort Huang, Chih-Yu
collection PubMed
description Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids. Mice were xenografted with human lung cancer cells; CB1a could significantly inhibit the growth of tumors in this in vivo model. Docetaxel is a drug in present clinical use against lung cancers; it can have serious side effects because its toxicity is not sufficiently limited to cancer cells. In our studies in mice: CB1a is more toxic to cancer cells than docetaxel, but dramatically less toxic to healthy cells.
format Online
Article
Text
id pubmed-4195615
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-41956152014-10-15 Inhibition Effect of a Custom Peptide on Lung Tumors Huang, Chih-Yu Huang, Hsuan-Yu Forrest, Michael D. Pan, Yun-Ru Wu, Wei-Jen Chen, Hueih-Min PLoS One Research Article Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids. Mice were xenografted with human lung cancer cells; CB1a could significantly inhibit the growth of tumors in this in vivo model. Docetaxel is a drug in present clinical use against lung cancers; it can have serious side effects because its toxicity is not sufficiently limited to cancer cells. In our studies in mice: CB1a is more toxic to cancer cells than docetaxel, but dramatically less toxic to healthy cells. Public Library of Science 2014-10-13 /pmc/articles/PMC4195615/ /pubmed/25310698 http://dx.doi.org/10.1371/journal.pone.0109174 Text en © 2014 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Huang, Chih-Yu
Huang, Hsuan-Yu
Forrest, Michael D.
Pan, Yun-Ru
Wu, Wei-Jen
Chen, Hueih-Min
Inhibition Effect of a Custom Peptide on Lung Tumors
title Inhibition Effect of a Custom Peptide on Lung Tumors
title_full Inhibition Effect of a Custom Peptide on Lung Tumors
title_fullStr Inhibition Effect of a Custom Peptide on Lung Tumors
title_full_unstemmed Inhibition Effect of a Custom Peptide on Lung Tumors
title_short Inhibition Effect of a Custom Peptide on Lung Tumors
title_sort inhibition effect of a custom peptide on lung tumors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195615/
https://www.ncbi.nlm.nih.gov/pubmed/25310698
http://dx.doi.org/10.1371/journal.pone.0109174
work_keys_str_mv AT huangchihyu inhibitioneffectofacustompeptideonlungtumors
AT huanghsuanyu inhibitioneffectofacustompeptideonlungtumors
AT forrestmichaeld inhibitioneffectofacustompeptideonlungtumors
AT panyunru inhibitioneffectofacustompeptideonlungtumors
AT wuweijen inhibitioneffectofacustompeptideonlungtumors
AT chenhueihmin inhibitioneffectofacustompeptideonlungtumors