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Inhibition Effect of a Custom Peptide on Lung Tumors
Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195615/ https://www.ncbi.nlm.nih.gov/pubmed/25310698 http://dx.doi.org/10.1371/journal.pone.0109174 |
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author | Huang, Chih-Yu Huang, Hsuan-Yu Forrest, Michael D. Pan, Yun-Ru Wu, Wei-Jen Chen, Hueih-Min |
author_facet | Huang, Chih-Yu Huang, Hsuan-Yu Forrest, Michael D. Pan, Yun-Ru Wu, Wei-Jen Chen, Hueih-Min |
author_sort | Huang, Chih-Yu |
collection | PubMed |
description | Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids. Mice were xenografted with human lung cancer cells; CB1a could significantly inhibit the growth of tumors in this in vivo model. Docetaxel is a drug in present clinical use against lung cancers; it can have serious side effects because its toxicity is not sufficiently limited to cancer cells. In our studies in mice: CB1a is more toxic to cancer cells than docetaxel, but dramatically less toxic to healthy cells. |
format | Online Article Text |
id | pubmed-4195615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41956152014-10-15 Inhibition Effect of a Custom Peptide on Lung Tumors Huang, Chih-Yu Huang, Hsuan-Yu Forrest, Michael D. Pan, Yun-Ru Wu, Wei-Jen Chen, Hueih-Min PLoS One Research Article Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids. Mice were xenografted with human lung cancer cells; CB1a could significantly inhibit the growth of tumors in this in vivo model. Docetaxel is a drug in present clinical use against lung cancers; it can have serious side effects because its toxicity is not sufficiently limited to cancer cells. In our studies in mice: CB1a is more toxic to cancer cells than docetaxel, but dramatically less toxic to healthy cells. Public Library of Science 2014-10-13 /pmc/articles/PMC4195615/ /pubmed/25310698 http://dx.doi.org/10.1371/journal.pone.0109174 Text en © 2014 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Huang, Chih-Yu Huang, Hsuan-Yu Forrest, Michael D. Pan, Yun-Ru Wu, Wei-Jen Chen, Hueih-Min Inhibition Effect of a Custom Peptide on Lung Tumors |
title | Inhibition Effect of a Custom Peptide on Lung Tumors |
title_full | Inhibition Effect of a Custom Peptide on Lung Tumors |
title_fullStr | Inhibition Effect of a Custom Peptide on Lung Tumors |
title_full_unstemmed | Inhibition Effect of a Custom Peptide on Lung Tumors |
title_short | Inhibition Effect of a Custom Peptide on Lung Tumors |
title_sort | inhibition effect of a custom peptide on lung tumors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195615/ https://www.ncbi.nlm.nih.gov/pubmed/25310698 http://dx.doi.org/10.1371/journal.pone.0109174 |
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