Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome

The von Hippel-Lindau (VHL) cancer syndrome is associated with mutations in the VHL gene. The pVHL protein is involved in response to changes in oxygen availability as part of an E3-ligase that targets the Hypoxia-Inducible Factor for degradation. pVHL has a molten globule configuration with margina...

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Detalles Bibliográficos
Autores principales: Shmueli, Merav D., Schnaider, Lee, Herzog, Gal, Gazit, Ehud, Segal, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195687/
https://www.ncbi.nlm.nih.gov/pubmed/25310726
http://dx.doi.org/10.1371/journal.pone.0109864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195687/
https://www.ncbi.nlm.nih.gov/pubmed/25310726
http://dx.doi.org/10.1371/journal.pone.0109864

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