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Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome
The von Hippel-Lindau (VHL) cancer syndrome is associated with mutations in the VHL gene. The pVHL protein is involved in response to changes in oxygen availability as part of an E3-ligase that targets the Hypoxia-Inducible Factor for degradation. pVHL has a molten globule configuration with margina...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195687/ https://www.ncbi.nlm.nih.gov/pubmed/25310726 http://dx.doi.org/10.1371/journal.pone.0109864 |