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Cytoskeletal Dependence of Insulin Granule Movement Dynamics in INS-1 Beta-Cells in Response to Glucose
For pancreatic β-cells to secrete insulin in response to elevated blood glucose, insulin granules retained within the subplasmalemmal space must be transported to sites of secretion on the plasma membrane. Using a combination of super-resolution STORM imaging and live cell TIRF microscopy we investi...
Autores principales: | Heaslip, Aoife T., Nelson, Shane R., Lombardo, Andrew T., Beck Previs, Samantha, Armstrong, Jessica, Warshaw, David M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195697/ https://www.ncbi.nlm.nih.gov/pubmed/25310693 http://dx.doi.org/10.1371/journal.pone.0109082 |
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