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Antiviral drugs specific for coronaviruses in preclinical development

Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses impeded the development of coronavirus specific therape...

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Detalles Bibliográficos
Autores principales: Adedeji, Adeyemi O, Sarafianos, Stefan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195804/
https://www.ncbi.nlm.nih.gov/pubmed/24997250
http://dx.doi.org/10.1016/j.coviro.2014.06.002
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author Adedeji, Adeyemi O
Sarafianos, Stefan G
author_facet Adedeji, Adeyemi O
Sarafianos, Stefan G
author_sort Adedeji, Adeyemi O
collection PubMed
description Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses impeded the development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV), and more recently, Middle East respiratory syndrome coronavirus (MERS-CoV), has impelled the development of such drugs. This review focuses on some newly identified SARS-CoV inhibitors, with known mechanisms of action and their potential to inhibit the novel MERS-CoV. The clinical development of optimized versions of such compounds could be beneficial for the treatment and control of SARS-CoV, the current MERS-CoV and other future SARS-like epidemics.
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spelling pubmed-41958042015-10-01 Antiviral drugs specific for coronaviruses in preclinical development Adedeji, Adeyemi O Sarafianos, Stefan G Curr Opin Virol Article Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses impeded the development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV), and more recently, Middle East respiratory syndrome coronavirus (MERS-CoV), has impelled the development of such drugs. This review focuses on some newly identified SARS-CoV inhibitors, with known mechanisms of action and their potential to inhibit the novel MERS-CoV. The clinical development of optimized versions of such compounds could be beneficial for the treatment and control of SARS-CoV, the current MERS-CoV and other future SARS-like epidemics. Elsevier B.V. 2014-10 2014-07-02 /pmc/articles/PMC4195804/ /pubmed/24997250 http://dx.doi.org/10.1016/j.coviro.2014.06.002 Text en Copyright © 2014 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Adedeji, Adeyemi O
Sarafianos, Stefan G
Antiviral drugs specific for coronaviruses in preclinical development
title Antiviral drugs specific for coronaviruses in preclinical development
title_full Antiviral drugs specific for coronaviruses in preclinical development
title_fullStr Antiviral drugs specific for coronaviruses in preclinical development
title_full_unstemmed Antiviral drugs specific for coronaviruses in preclinical development
title_short Antiviral drugs specific for coronaviruses in preclinical development
title_sort antiviral drugs specific for coronaviruses in preclinical development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195804/
https://www.ncbi.nlm.nih.gov/pubmed/24997250
http://dx.doi.org/10.1016/j.coviro.2014.06.002
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