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Multiple mechanisms determine the order of APC/C substrate degradation in mitosis

The ubiquitin protein ligase anaphase-promoting complex or cyclosome (APC/C) controls mitosis by promoting ordered degradation of securin, cyclins, and other proteins. The mechanisms underlying the timing of APC/C substrate degradation are poorly understood. We explored these mechanisms using quanti...

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Detalles Bibliográficos
Autores principales:	Lu, Dan, Hsiao, Jennifer Y., Davey, Norman E., Van Voorhis, Vanessa A., Foster, Scott A., Tang, Chao, Morgan, David O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195823/ https://www.ncbi.nlm.nih.gov/pubmed/25287299 http://dx.doi.org/10.1083/jcb.201402041

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