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High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)

BACKGROUND: Matrix metalloproteinase-2 (MMP-2) is an endopeptidase that facilitates extracellular matrix remodeling and molecular regulation, and is implicated in tumor metastasis. Type I collagen (Col I) regulates the activation of MMP-2 through both transcriptional and post-transcriptional means;...

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Detalles Bibliográficos
Autores principales:	Borrirukwanit, Kulrut, Pavasant, Prasit, Blick, Tony, Lafleur, Marc A, Thompson, Erik W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195858/ https://www.ncbi.nlm.nih.gov/pubmed/25317077 http://dx.doi.org/10.1186/s12935-014-0099-3

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