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The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO). METHODS: The study population included 225 patients, a control group...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195893/ https://www.ncbi.nlm.nih.gov/pubmed/25260530 http://dx.doi.org/10.1186/1471-2261-14-130 |
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author | Demir, Kenan Avci, Ahmet Altunkeser, Bulent Behlul Yilmaz, Ahmet Keles, Fikret Ersecgin, Ahmet |
author_facet | Demir, Kenan Avci, Ahmet Altunkeser, Bulent Behlul Yilmaz, Ahmet Keles, Fikret Ersecgin, Ahmet |
author_sort | Demir, Kenan |
collection | PubMed |
description | BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO). METHODS: The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups. RESULTS: NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68–0.81), with a specificity of 69.3% and a sensitivity of 61%. CONCLUSION: NLR may be useful as a marker of CTO. |
format | Online Article Text |
id | pubmed-4195893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41958932014-10-15 The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions Demir, Kenan Avci, Ahmet Altunkeser, Bulent Behlul Yilmaz, Ahmet Keles, Fikret Ersecgin, Ahmet BMC Cardiovasc Disord Research Article BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO). METHODS: The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups. RESULTS: NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68–0.81), with a specificity of 69.3% and a sensitivity of 61%. CONCLUSION: NLR may be useful as a marker of CTO. BioMed Central 2014-09-27 /pmc/articles/PMC4195893/ /pubmed/25260530 http://dx.doi.org/10.1186/1471-2261-14-130 Text en © Demir et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Demir, Kenan Avci, Ahmet Altunkeser, Bulent Behlul Yilmaz, Ahmet Keles, Fikret Ersecgin, Ahmet The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions |
title | The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions |
title_full | The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions |
title_fullStr | The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions |
title_full_unstemmed | The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions |
title_short | The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions |
title_sort | relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195893/ https://www.ncbi.nlm.nih.gov/pubmed/25260530 http://dx.doi.org/10.1186/1471-2261-14-130 |
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