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Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells

BACKGROUND: Granzyme B (GrzB) is a serine proteinase expressed by memory T cells and NK cells. Methods to measure GrzB protein usually involve intracellular (flow cytometry) and extracellular (ELISA and ELISpot) assays. CD8 T cells are the main source of GrzB during immunological reactions, but acti...

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Detalles Bibliográficos
Autores principales:	Lin, Lin, Couturier, Jacob, Yu, Xiaoying, Medina, Miguel A, Kozinetz, Claudia A, Lewis, Dorothy E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195902/ https://www.ncbi.nlm.nih.gov/pubmed/25245659 http://dx.doi.org/10.1186/s12865-014-0036-1

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