A novel small-molecule MRCK inhibitor blocks cancer cell invasion

BACKGROUND: The myotonic dystrophy kinase-related CDC42-binding kinases MRCKα and MRCKβ regulate actin-myosin contractility and have been implicated in cancer metastasis. Along with the related ROCK1 and ROCK2 kinases, the MRCK proteins initiate signalling events that lead to contractile force gener...

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Detalles Bibliográficos
Autores principales: Unbekandt, Mathieu, Croft, Daniel R, Crighton, Diane, Mezna, Mokdad, McArthur, Duncan, McConnell, Patricia, Schüttelkopf, Alexander W, Belshaw, Simone, Pannifer, Andrew, Sime, Mairi, Bower, Justin, Drysdale, Martin, Olson, Michael F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195943/
https://www.ncbi.nlm.nih.gov/pubmed/25288205
http://dx.doi.org/10.1186/s12964-014-0054-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195943/
https://www.ncbi.nlm.nih.gov/pubmed/25288205
http://dx.doi.org/10.1186/s12964-014-0054-x

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