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Does Intra Articular Platelet Rich Plasma Injection Improve Function, Pain and Quality of Life in Patients with Osteoarthritis of the Knee? A Randomized Clinical Trial

We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exerc...

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Autores principales: Rayegani, Seyed Mansoor, Raeissadat, Seyed Ahmad, Taheri, Morteza Sanei, Babaee, Marzieh, Bahrami, Mohammad Hassan, Eliaspour, Dariush, Ghorbani, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195987/
https://www.ncbi.nlm.nih.gov/pubmed/25317308
http://dx.doi.org/10.4081/or.2014.5405
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author Rayegani, Seyed Mansoor
Raeissadat, Seyed Ahmad
Taheri, Morteza Sanei
Babaee, Marzieh
Bahrami, Mohammad Hassan
Eliaspour, Dariush
Ghorbani, Elham
author_facet Rayegani, Seyed Mansoor
Raeissadat, Seyed Ahmad
Taheri, Morteza Sanei
Babaee, Marzieh
Bahrami, Mohammad Hassan
Eliaspour, Dariush
Ghorbani, Elham
author_sort Rayegani, Seyed Mansoor
collection PubMed
description We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University’s Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.
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spelling pubmed-41959872014-10-14 Does Intra Articular Platelet Rich Plasma Injection Improve Function, Pain and Quality of Life in Patients with Osteoarthritis of the Knee? A Randomized Clinical Trial Rayegani, Seyed Mansoor Raeissadat, Seyed Ahmad Taheri, Morteza Sanei Babaee, Marzieh Bahrami, Mohammad Hassan Eliaspour, Dariush Ghorbani, Elham Orthop Rev (Pavia) Article We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University’s Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone. PAGEPress Publications, Pavia, Italy 2014-09-18 /pmc/articles/PMC4195987/ /pubmed/25317308 http://dx.doi.org/10.4081/or.2014.5405 Text en ©Copyright S.M.Rayegani et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Rayegani, Seyed Mansoor
Raeissadat, Seyed Ahmad
Taheri, Morteza Sanei
Babaee, Marzieh
Bahrami, Mohammad Hassan
Eliaspour, Dariush
Ghorbani, Elham
Does Intra Articular Platelet Rich Plasma Injection Improve Function, Pain and Quality of Life in Patients with Osteoarthritis of the Knee? A Randomized Clinical Trial
title Does Intra Articular Platelet Rich Plasma Injection Improve Function, Pain and Quality of Life in Patients with Osteoarthritis of the Knee? A Randomized Clinical Trial
title_full Does Intra Articular Platelet Rich Plasma Injection Improve Function, Pain and Quality of Life in Patients with Osteoarthritis of the Knee? A Randomized Clinical Trial
title_fullStr Does Intra Articular Platelet Rich Plasma Injection Improve Function, Pain and Quality of Life in Patients with Osteoarthritis of the Knee? A Randomized Clinical Trial
title_full_unstemmed Does Intra Articular Platelet Rich Plasma Injection Improve Function, Pain and Quality of Life in Patients with Osteoarthritis of the Knee? A Randomized Clinical Trial
title_short Does Intra Articular Platelet Rich Plasma Injection Improve Function, Pain and Quality of Life in Patients with Osteoarthritis of the Knee? A Randomized Clinical Trial
title_sort does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? a randomized clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195987/
https://www.ncbi.nlm.nih.gov/pubmed/25317308
http://dx.doi.org/10.4081/or.2014.5405
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