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Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1

BACKGROUND: Molecular mechanisms involved in the oxidative stress induced glucocorticoids insensitivity remain elusive. The mitogen-activated protein kinase phosphatase (MKP) 1 mediates a part of glucocorticoids action and can be modified by exogenous oxidants. Whether oxidant ozone (O(3)) can affec...

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Detalles Bibliográficos
Autores principales:	Bao, Aihua, Li, Feng, Zhang, Min, Chen, Yuqing, Zhang, Pengyu, Zhou, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196074/ https://www.ncbi.nlm.nih.gov/pubmed/25287866 http://dx.doi.org/10.1186/s12931-014-0126-x

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