Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma

Phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis and drug resistance. Antitumor activity has been observed with mTOR inhibitors. However, they have shown limited clinical efficacy in relation to dr...

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Detalles Bibliográficos
Autores principales: Rosich, Laia, Montraveta, Arnau, Xargay-Torrent, Sílvia, López-Guerra, Mónica, Roldán, Jocabed, Aymerich, Marta, Salaverria, Itziar, Beà, Sílvia, Campo, Elías, Pérez-Galán, Patricia, Roué, Gaël, Colomer, Dolors
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196163/
https://www.ncbi.nlm.nih.gov/pubmed/25216518

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