Release of Ca(2+) from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells

Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine”, is known to have anticancer activity, but its underlying mechanism is not completely understood. In this study, we show that celastrol kills several breast and colon cancer cell lines by induction of paraptosis, a cell death m...

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Detalles Bibliográficos
Autores principales: Yoon, Mi Jin, Lee, A Reum, Jeong, Soo Ah, Kim, You-Sun, Kim, Jin Yeop, Kwon, Yong-Jun, Choi, Kyeong Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196165/
https://www.ncbi.nlm.nih.gov/pubmed/25149175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196165/
https://www.ncbi.nlm.nih.gov/pubmed/25149175

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