Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes

Downregulation of MHC class I expression on tumour cells, a common mechanism by which tumour cells can escape from specific immune responses, can be associated with coordinated silencing of antigen-presenting machinery genes. The expression of these genes can be restored by IFNγ. In this study we do...

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Detalles Bibliográficos
Autores principales: Vlková, Veronika, Štěpánek, Ivan, Hrušková, Veronika, Šenigl, Filip, Mayerová, Veronika, Šrámek, Martin, Šímová, Jana, Bieblová, Jana, Indrová, Marie, Hejhal, Tomáš, Dérian, Nicolas, Klatzmann, David, Six, Adrien, Reiniš, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196173/
https://www.ncbi.nlm.nih.gov/pubmed/25071011

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