Cargando…

Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case

The intriguing array of spindle cell lesions occurring, especially in the head and neck region, poses a critical diagnostic challenge not only to the histopathologist but also ultimately to the clinicians for planning an appropriate treatment protocol. Overlapping spectrum of clinico-radiographic an...

Descripción completa

Detalles Bibliográficos
Autores principales: Rath, Rachna, Das, Bijay K, Das, SN, Baisakh, Manas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196296/
https://www.ncbi.nlm.nih.gov/pubmed/25328308
http://dx.doi.org/10.4103/0973-029X.140772
_version_ 1782339459509911552
author Rath, Rachna
Das, Bijay K
Das, SN
Baisakh, Manas
author_facet Rath, Rachna
Das, Bijay K
Das, SN
Baisakh, Manas
author_sort Rath, Rachna
collection PubMed
description The intriguing array of spindle cell lesions occurring, especially in the head and neck region, poses a critical diagnostic challenge not only to the histopathologist but also ultimately to the clinicians for planning an appropriate treatment protocol. Overlapping spectrum of clinico-radiographic and microscopic features further compounds this problem. In such situations, the aid of ancillary techniques like immunohistochemistry (IHC) is sought to clinch the diagnosis. But is the diagnosis based on IHC most decisive? Probably the answer lies in the Pandora's Box. This paper analyzed the potential doubts, apprehensions and the reliability that is singularly based on the morphological spindle appearance of an abnormal cell that has deviated from the usual clinical and microscopic presentation and thus posed a diagnostic dilemma warranting more questions than the answers. We review the etiopathogenesis of this entity and its differential diagnosis from few other spindle cell lesions of head and neck with special reference to use of immunohistochemical markers, with a case study.
format Online
Article
Text
id pubmed-4196296
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-41962962014-10-17 Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case Rath, Rachna Das, Bijay K Das, SN Baisakh, Manas J Oral Maxillofac Pathol Case Report The intriguing array of spindle cell lesions occurring, especially in the head and neck region, poses a critical diagnostic challenge not only to the histopathologist but also ultimately to the clinicians for planning an appropriate treatment protocol. Overlapping spectrum of clinico-radiographic and microscopic features further compounds this problem. In such situations, the aid of ancillary techniques like immunohistochemistry (IHC) is sought to clinch the diagnosis. But is the diagnosis based on IHC most decisive? Probably the answer lies in the Pandora's Box. This paper analyzed the potential doubts, apprehensions and the reliability that is singularly based on the morphological spindle appearance of an abnormal cell that has deviated from the usual clinical and microscopic presentation and thus posed a diagnostic dilemma warranting more questions than the answers. We review the etiopathogenesis of this entity and its differential diagnosis from few other spindle cell lesions of head and neck with special reference to use of immunohistochemical markers, with a case study. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4196296/ /pubmed/25328308 http://dx.doi.org/10.4103/0973-029X.140772 Text en Copyright: © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rath, Rachna
Das, Bijay K
Das, SN
Baisakh, Manas
Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case
title Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case
title_full Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case
title_fullStr Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case
title_full_unstemmed Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case
title_short Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case
title_sort spindle cell carcinoma of maxilla: histomorphological and immunohistochemical analysis of a case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196296/
https://www.ncbi.nlm.nih.gov/pubmed/25328308
http://dx.doi.org/10.4103/0973-029X.140772
work_keys_str_mv AT rathrachna spindlecellcarcinomaofmaxillahistomorphologicalandimmunohistochemicalanalysisofacase
AT dasbijayk spindlecellcarcinomaofmaxillahistomorphologicalandimmunohistochemicalanalysisofacase
AT dassn spindlecellcarcinomaofmaxillahistomorphologicalandimmunohistochemicalanalysisofacase
AT baisakhmanas spindlecellcarcinomaofmaxillahistomorphologicalandimmunohistochemicalanalysisofacase